About the Authors
- Fumiko Matsuoka
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Contributed equally to this work with: Fumiko Matsuoka, Ichiro Takeuchi
Affiliation Department of Biotechnology, Graduate School of Engineering, Nagoya University, Nagoya, Aichi, Japan
- Ichiro Takeuchi
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Contributed equally to this work with: Fumiko Matsuoka, Ichiro Takeuchi
Affiliation Department of Engineering, Nagoya Institute of Technology, Nagoya, Aichi, Japan
- Hideki Agata
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Affiliation Tissue Engineering Research Group, Division of Molecular Therapy, The Institute of Medical Science The University of Tokyo, Tokyo, Japan
- Hideaki Kagami
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Affiliations Tissue Engineering Research Group, Division of Molecular Therapy, The Institute of Medical Science The University of Tokyo, Tokyo, Japan, Department of Oral and Maxillofacial Surgery, Matsumoto Dental University School of Dentistry, Shiojiri, Nagano, Japan
- Hirofumi Shiono
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Affiliation Nikon Corporation, Tokyo, Japan
- Yasujiro Kiyota
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Affiliation Nikon Corporation, Tokyo, Japan
- Hiroyuki Honda
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Affiliation Department of Biotechnology, Graduate School of Engineering, Nagoya University, Nagoya, Aichi, Japan
- Ryuji Kato
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* E-mail: kato-r@ps.nagoya-u.ac.jp
Affiliations Department of Biotechnology, Graduate School of Engineering, Nagoya University, Nagoya, Aichi, Japan, Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya, Aichi, Japan
Competing Interests
We have the following interests. This study was supported in part by a grant-in-aid from Nikon Corporation. Hirofumi Shiono and Yasujiro Kiyota are employed by Nikon Instruments. Ryuji Kato is one of the main investigators of 12 patents (pending) related to basic technologies of “algorithms of cellular image processing. Hirofumi Shiono, is one of the inventors of the hardware we used in our research, “BioStaion CT” which is the automatic cell culture system, and a member of this collaborative project with Nagoya Univ. The BioStation CT and relating software are marketed products of Nikon Corporation. Although the system and the software were used in this study, the result of this research does not depend on the system and the software. He is one of the inventors of related 12 patents. Yasujiro Kiyota, is one of the inventors of the hardware we used in our research work. There are no further patents, products in development or marketed products to declare. This does not alter our adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors.
Author Contributions
Conceived and designed the experiments: FM HK HA RK. Performed the experiments: FM. Analyzed the data: IT FM RK. Contributed reagents/materials/analysis tools: HS YK HH RK. Wrote the paper: FM IT HK HA RK.