About the Authors

Richard A. Jensen

richaj@uw.edu

# First author from each of the cohorts involved in the study.

Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America

Xueling Sim

# First author from each of the cohorts involved in the study.

Affiliation Centre for Molecular Epidemiology, National University of Singapore, Singapore, Singapore

Xiaohui Li

# First author from each of the cohorts involved in the study.

Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

Mary Frances Cotch

# First author from each of the cohorts involved in the study.

Affiliation Division of Epidemiology and Clinical Applications, National Eye Institute, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, United States of America

M. Kamran Ikram

# First author from each of the cohorts involved in the study.

Affiliations Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands

Elizabeth G. Holliday

# First author from each of the cohorts involved in the study.

Affiliation School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia

Gudny Eiriksdottir

Affiliation Icelandic Heart Association, Kopavogur, Iceland

Tamara B. Harris

Affiliation Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, United States of America

Fridbert Jonasson

Affiliations Department of Medicine, University of Iceland, Reykjavik, Iceland, Department of Ophthalmology, Landspitalinn University Hospital, Reykjavik, Iceland

Barbara E. K. Klein

Affiliation Department of Ophthalmology and Visual Science, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America

Lenore J. Launer

Affiliation Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, United States of America

Albert Vernon Smith

Affiliations Icelandic Heart Association, Kopavogur, Iceland, Department of Medicine, University of Iceland, Reykjavik, Iceland

Eric Boerwinkle

Affiliation Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America

Ning Cheung

Affiliation Centre for Eye Research Australia, University of Melbourne, East Melbourne, Victoria, Australia

Alex W. Hewitt

Affiliation Centre for Eye Research Australia, University of Melbourne, East Melbourne, Victoria, Australia

Gerald Liew

Affiliations Centre for Eye Research Australia, University of Melbourne, East Melbourne, Victoria, Australia, Centre for Vision Research, Department of Ophthalmology and the Westmead Millennium Institute, University of Sydney, Sydney, Australia

Paul Mitchell

Affiliation Centre for Vision Research, Department of Ophthalmology and the Westmead Millennium Institute, University of Sydney, Sydney, Australia

Jie Jin Wang

Affiliations Centre for Eye Research Australia, University of Melbourne, East Melbourne, Victoria, Australia, Centre for Vision Research, Department of Ophthalmology and the Westmead Millennium Institute, University of Sydney, Sydney, Australia

John Attia

Affiliations School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia, Department of Medicine, John Hunter Hospital and Hunter Medical Research Institute, Newcastle, New South Wales, Australia

Rodney Scott

Affiliation School of Biomedical Sciences, University of Newcastle, Newcastle, New South Wales, Australia

Nicole L. Glazer

Affiliation Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts, United States of America

Thomas Lumley

Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Statistics, University of Auckland, Auckland, New Zealand

Barbara McKnight

Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

Bruce M. Psaty

Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, Department of Health Services, University of Washington, Seattle, Washington, United States of America, Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America

Kent Taylor

Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

Albert Hofman

Affiliation Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

Paulus T. V. M. de Jong

Affiliations Netherlands Institute of Neuroscience, Amsterdam, The Netherlands, Department of Ophthalmology, Academic Medical Center, Amsterdam, The Netherlands

Fernando Rivadeneira

Affiliations Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

Andre G. Uitterlinden

Affiliations Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Clinical Chemistry, Erasmus Medical Center, Rotterdam, The Netherlands

Wan-Ting Tay

Affiliation Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore

Yik Ying Teo

Affiliations Centre for Molecular Epidemiology, National University of Singapore, Singapore, Singapore, Department of Epidemiology and Public Health, National University of Singapore, Singapore, Singapore, Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore, NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore, Singapore, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore

Mark Seielstad

Affiliation Institute of Human Genetics, University of California San Francisco, San Francisco, California United States of America

Jianjun Liu

Affiliation Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore

Ching-Yu Cheng

Affiliations Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Department of Epidemiology and Public Health, National University of Singapore, Singapore, Singapore, Department of Ophthalmology, National University of Singapore, Singapore, Singapore

Seang-Mei Saw

Affiliations Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Department of Epidemiology and Public Health, National University of Singapore, Singapore, Singapore, Department of Ophthalmology, National University of Singapore, Singapore, Singapore

Tin Aung

Affiliations Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Department of Ophthalmology, National University of Singapore, Singapore, Singapore

Santhi K. Ganesh

Affiliation Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

Christopher J. O'Donnell

Affiliations National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, United States of America, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Mike A. Nalls

Affiliation Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Kerri L. Wiggins

Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America

Jane Z. Kuo

Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

The Blue Mountains Eye Study GWAS team

‡ Membership is provided in the acknowledgements.

CKDGen Consortium

‡ Membership is provided in the acknowledgements.

Cornelia M. van Duijn

Senior author from each of the cohorts involved in the study.

Affiliation Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

Vilmundur Gudnason

Senior author from each of the cohorts involved in the study.

Affiliations Icelandic Heart Association, Kopavogur, Iceland, Department of Medicine, University of Iceland, Reykjavik, Iceland

Ronald Klein

Senior author from each of the cohorts involved in the study.

Affiliation Department of Ophthalmology and Visual Science, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America

David S. Siscovick

Senior author from each of the cohorts involved in the study.

Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

Jerome I. Rotter

Senior author from each of the cohorts involved in the study.

Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

E. Shong Tai

Senior author from each of the cohorts involved in the study.

Affiliations Department of Epidemiology and Public Health, National University of Singapore, Singapore, Singapore, Department of Medicine, National University of Singapore, Singapore, Singapore, Duke-National University of Singapore Graduate Medical School, Singapore, Singapore

Johannes Vingerling

Senior author from each of the cohorts involved in the study.

Affiliations Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

Tien Y. Wong

Senior author from each of the cohorts involved in the study.

Affiliations Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Centre for Eye Research Australia, University of Melbourne, East Melbourne, Victoria, Australia, Department of Ophthalmology, National University of Singapore, Singapore, Singapore

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

‡ ‡ Membership is provided in the acknowledgements.

Conceived and designed the experiments: MFC GE TBH FJ BEKK LJL AVS EB JJW TL BMP AH PTVMDJ MS JL SMS TA CJO CMVD VG RK DSS JIR EST JV TYW. Performed the experiments: EGH GE FJ EB NLG KT FR AGU CJO JIR JV. Analyzed the data: RAJ XS XL MFC MKI EGH AVS NC AWH GL WTT YYT CYC SKG CJO MAN KLW JZK. Contributed reagents/materials/analysis tools: MFC GE TBH BEKK LJL AVS EB PM JJW JA RS TL BMP FR AGU BMES VG RK DSS JIR. Wrote the paper: RAJ XS MFC MKI EGH GE BEKK AVS EB PM JJW JA RS BM BMP AH PTVMDJ SKG CJO CMVD VG RK DSS JIR EST JV TYW.