About the Authors

José Manuel Otero

Current address: Vaccine & Biologics Process Development, Bioprocess Research & Development, Merck Research Labs, West Point, Pennsylvania, United States of America

Affiliations Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden, Center for Microbial Biotechnology, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark

Donatella Cimini

Affiliation Department of Experimental Medicine, Second University of Naples, Naples, Italy

Kiran R. Patil

Current address: Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany

Affiliation Center for Microbial Biotechnology, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark

Simon G. Poulsen

Affiliation Center for Microbial Biotechnology, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark

Lisbeth Olsson

Affiliations Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden, Center for Microbial Biotechnology, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark

Jens Nielsen

nielsenj@chalmers.se

Affiliations Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden, Center for Microbial Biotechnology, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark

Competing Interests

The authors have the following interests: Jose Manuel Otero is employed by Merck, the funder of this study. During his PhD study in Nielsen lab, he was financed by a PhD scholarship by Merck. The research work of his PhD is of no commercial interest to Merck. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: JMO DC KRP LO JN. Performed the experiments: JMO DC SGP. Analyzed the data: JMO DC JN. Wrote the paper: JMO JN.