About the Authors

Maria Azrad

maria123@uab.edu

Affiliation Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Kui Zhang

Affiliation Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America

Robin T. Vollmer

Affiliations Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Surgical Pathology & Cytopathology, Durham Veterans Affair Medical Center, Durham, North Carolina, United States of America

John Madden

Affiliation Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America

Thomas J. Polascik

Affiliation Department of Surgery and Duke Prostate Center, Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, United States of America

Denise C. Snyder

Affiliation Department of Clinical Research, Duke University Medical Center, Durham, North Carolina, United States of America

Mack T. Ruffin

Affiliation Department of Family Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

Judd W. Moul

Affiliation Department of Surgery and Duke Prostate Center, Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, United States of America

Dean Brenner

Affiliations Department of Family Medicine, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

Robert W. Hardy

Affiliations Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Wendy Demark-Wahnefried

Affiliation Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Competing Interests

The flaxseed used in the study was donated by ENRECO, Inc. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MA WDW. Performed the experiments: RTV JM. Analyzed the data: MA KZ. Wrote the paper: MA KZ WDW. Helped in the selestion of participants: TJP JWM. Conducted nutritional assessments of participants: DCS. Provided input into the study design, manuscript preparation and editing: MTR DB RWH.