About the Authors

Miguel Ángel Muñoz-Ruiz

Affiliation Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland

Päivi Hartikainen

Affiliations Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland, Department of Neurology, Kuopio University Hospital, Kuopio, Finland

Juha Koikkalainen

Affiliation Knowledge Intensive Services, VTT Technical Research Centre of Finland, Tampere, Finland

Robin Wolz

Affiliation Biomedical Image Analysis Group, Department of Computing, Imperial College London, London, United Kingdom

Valtteri Julkunen

Affiliations Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland, Department of Neurology, Kuopio University Hospital, Kuopio, Finland

Eini Niskanen

Affiliation Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland

Sanna-Kaisa Herukka

Affiliation Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland

Miia Kivipelto

Affiliations Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland, Aging Research Centre, Karolinska Institutet, Stockholm, Sweden

Ritva Vanninen

Affiliation Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland

Daniel Rueckert

Affiliation Biomedical Image Analysis Group, Department of Computing, Imperial College London, London, United Kingdom

Yawu Liu

Affiliations Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland, Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland

Jyrki Lötjönen

Affiliation Knowledge Intensive Services, VTT Technical Research Centre of Finland, Tampere, Finland

Hilkka Soininen

hilkka.soininen@uef.fi

Affiliations Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland, Department of Neurology, Kuopio University Hospital, Kuopio, Finland

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MMR PH JK JL HS. Performed the experiments: MMR JK JL HS. Analyzed the data: MMR JK JL HS. Contributed reagents/materials/analysis tools: PH JK RW VJ EN SKH MK RV DR JL HS. Wrote the paper: MMR PH JK JL HS. Critically revised the paper: RW VJ EN SKH MK RV DR YL.