About the Authors

Eva Mathieu

Affiliations INSERM UMR1087, CNRS UMR6291, l’institut du thorax, Nantes, France, Université de Nantes, Structure Fédérative de Recherche Santé F. Bonamy, Nantes, France

Guillaume Lamirault

Affiliations INSERM UMR1087, CNRS UMR6291, l’institut du thorax, Nantes, France, Université de Nantes, Structure Fédérative de Recherche Santé F. Bonamy, Nantes, France, CHU de Nantes, Nantes, France

Claire Toquet

Affiliations CHU de Nantes, Nantes, France, Service d’Anatomie Pathologique, E.A. Biometadys, CHU de Nantes, Nantes, France

Pierre Lhommet

Affiliations INSERM UMR1087, CNRS UMR6291, l’institut du thorax, Nantes, France, Université de Nantes, Structure Fédérative de Recherche Santé F. Bonamy, Nantes, France

Emilie Rederstorff

Affiliations Université de Nantes, Structure Fédérative de Recherche Santé F. Bonamy, Nantes, France, INSERM, U791, Laboratory of Osteo-Articular and Dental Tissue Engineering, Group STEP “Skeletal tissue Engineering and Physiopathology”, Nantes, France

Sophie Sourice

Affiliations Université de Nantes, Structure Fédérative de Recherche Santé F. Bonamy, Nantes, France, INSERM, U791, Laboratory of Osteo-Articular and Dental Tissue Engineering, Group STEP “Skeletal tissue Engineering and Physiopathology”, Nantes, France

Kevin Biteau

Affiliations INSERM UMR1087, CNRS UMR6291, l’institut du thorax, Nantes, France, Université de Nantes, Structure Fédérative de Recherche Santé F. Bonamy, Nantes, France

Philippe Hulin

Affiliations Université de Nantes, Structure Fédérative de Recherche Santé F. Bonamy, Nantes, France, Cellular and Tissular Imaging Core Facility of Nantes University (MicroPICell), Nantes, France

Virginie Forest

Affiliations INSERM UMR1087, CNRS UMR6291, l’institut du thorax, Nantes, France, Université de Nantes, Structure Fédérative de Recherche Santé F. Bonamy, Nantes, France

Pierre Weiss

Affiliations Université de Nantes, Structure Fédérative de Recherche Santé F. Bonamy, Nantes, France, CHU de Nantes, Nantes, France, INSERM, U791, Laboratory of Osteo-Articular and Dental Tissue Engineering, Group STEP “Skeletal tissue Engineering and Physiopathology”, Nantes, France

Jérôme Guicheux

Contributed equally to this work with: Jérôme Guicheux, Patricia Lemarchand

Affiliations Université de Nantes, Structure Fédérative de Recherche Santé F. Bonamy, Nantes, France, INSERM, U791, Laboratory of Osteo-Articular and Dental Tissue Engineering, Group STEP “Skeletal tissue Engineering and Physiopathology”, Nantes, France

Patricia Lemarchand

Contributed equally to this work with: Jérôme Guicheux, Patricia Lemarchand

patricia.lemarchand@univ-nantes.fr

Affiliations INSERM UMR1087, CNRS UMR6291, l’institut du thorax, Nantes, France, Université de Nantes, Structure Fédérative de Recherche Santé F. Bonamy, Nantes, France, CHU de Nantes, Nantes, France

Competing Interests

Co-author Jerome Guicheux is a PLOS ONE Editorial Board member. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: EM GL PW JG P. Lemarchand. Performed the experiments: EM CT P. Lhommet ER KB PH VF. Analyzed the data: EM GL CT PW JG P. Lemarchand. Contributed reagents/materials/analysis tools: EM GL. Wrote the paper: EM GL CT PW JG PL. Statistic analysis: EM GL. English language: EM GL P. Lemarchand.