Isoflurane Induces Learning Impairment That Is Mediated by Interleukin 1β in Rodents

Lin Cao; Liaoliao Li; Daowei Lin; Zhiyi Zuo

doi:10.1371/journal.pone.0051431

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Open Access

Peer-reviewed

Research Article

Isoflurane Induces Learning Impairment That Is Mediated by Interleukin 1β in Rodents

Lin Cao,

Affiliations Department of Anesthesiology, University of Virginia, Charlottesville, Virginia, United States of America, Department of Anesthesiology, Sun-Yat-Sen Memorial Hospital, Sun-Yat-Sen University, Guangzhou, Guangdong, China
⨯
Liaoliao Li,

Affiliation Department of Anesthesiology, University of Virginia, Charlottesville, Virginia, United States of America
⨯
Daowei Lin,

Affiliations Department of Anesthesiology, University of Virginia, Charlottesville, Virginia, United States of America, Department of Anesthesiology, Sun-Yat-Sen Memorial Hospital, Sun-Yat-Sen University, Guangzhou, Guangdong, China
⨯
Zhiyi Zuo

* E-mail: zz3c@virginia.edu

Affiliations Department of Anesthesiology, University of Virginia, Charlottesville, Virginia, United States of America, Department of Anesthesiology, Sun-Yat-Sen Memorial Hospital, Sun-Yat-Sen University, Guangzhou, Guangdong, China
⨯

Isoflurane Induces Learning Impairment That Is Mediated by Interleukin 1β in Rodents

Lin Cao,
Liaoliao Li,
Daowei Lin,
Zhiyi Zuo

Published: December 12, 2012
https://doi.org/10.1371/journal.pone.0051431

About the Authors

Lin Cao

Affiliations Department of Anesthesiology, University of Virginia, Charlottesville, Virginia, United States of America, Department of Anesthesiology, Sun-Yat-Sen Memorial Hospital, Sun-Yat-Sen University, Guangzhou, Guangdong, China

Liaoliao Li

Affiliation Department of Anesthesiology, University of Virginia, Charlottesville, Virginia, United States of America

Daowei Lin

Zhiyi Zuo

* E-mail: zz3c@virginia.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LC LL ZZ. Performed the experiments: LC LL DL. Analyzed the data: LC LL DL ZZ. Wrote the paper: LC LL ZZ.

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Cognitive impairment
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Hippocampus
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Fear conditioning
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Anesthetics
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Rats
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Learning
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Cytokines
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Surgical and invasive medical procedures
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