About the Authors

Ying Wang

Affiliation Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, United States of America

Hui-Chyn Wong

Affiliation Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, United States of America

Elizabeth A. Gullen

Affiliation Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, United States of America

Wing Lam

Affiliation Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, United States of America

Xiaoming Yang

Affiliation Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States of America

Qian Shi

Affiliation Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States of America

Kuo-Hsiung Lee

yccheng@yale.edu (YCC); khlee@unc.edu (KHL)

Affiliations Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States of America, Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung, Taiwan

Yung-Chi Cheng

yccheng@yale.edu (YCC); khlee@unc.edu (KHL)

Affiliation Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YW KHL YCC. Performed the experiments: YW HCW EAG WL. Analyzed the data: YW. Wrote the paper: YW KHL YCC. Synthesized the cryptopleurine analogs: XY QS.