About the Authors
- Brian D. Lawrence
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Contributed equally to this work with: Brian D. Lawrence, Zhi Pan
Affiliation Department of Biomedical Engineering, Cornell University, Ithaca, New York, United States of America
- Zhi Pan
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Contributed equally to this work with: Brian D. Lawrence, Zhi Pan
Affiliation Department of Ophthalmology, Weill Cornell Medical College, New York, New York, United States of America
- Mark I. Rosenblatt
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* E-mail: mar2058@med.cornell.edu
Affiliation Department of Ophthalmology, Weill Cornell Medical College, New York, New York, United States of America
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
Contributed reagents/materials/analysis tools: MIR. Wrote the paper: BL. Conceived and designed the patterned silk film surfaces: BL MIR. Conceived and designed the silk film culture system: BL ZP. Conceived and designed the cell sheet culture experiments: ZP MIR. Conceived and designed the western blot experiments: ZP. Performed the experiments for producing the silk film surfaces: BL. Performed the experiments to validate the culture system: BL ZP. Performed the cell sheet experiments and western blots: ZP. Analyzed the cell sheet aspect ratio data, actin and focal adhesion analysis data, and western blot data: ZP. Analyzed cell sheet migration data, single cell migration data, and cell proliferation data: BL. Contributed to cell sheet migration analysis: MIR. Wrote initial draft of introduction, methods and materials, and results sections: ZP. Assisted in editing: MIR.