About the Authors

David J. Pinato

Affiliation The National Institute for Health Research (NIHR)-Wellcome Trust Imperial College Clinical Research Facility, Imperial Centre for Translational and Experimental Medicine, Imperial College, Hammersmith Hospital Campus, London, United Kingdom

Chara Stavraka

Affiliation The National Institute for Health Research (NIHR)-Wellcome Trust Imperial College Clinical Research Facility, Imperial Centre for Translational and Experimental Medicine, Imperial College, Hammersmith Hospital Campus, London, United Kingdom

Mark Tanner

Affiliation Imanova Centre for Imaging Sciences, London, United Kingdom

Audrey Esson

Affiliation The National Institute for Health Research (NIHR)-Wellcome Trust Imperial College Clinical Research Facility, Imperial Centre for Translational and Experimental Medicine, Imperial College, Hammersmith Hospital Campus, London, United Kingdom

Eric W. Jacobson

Affiliation Sirtris Pharmaceuticals Inc., Cambridge, Massachusetts, United States of America

Martin R. Wilkins

Affiliation The National Institute for Health Research (NIHR)-Wellcome Trust Imperial College Clinical Research Facility, Imperial Centre for Translational and Experimental Medicine, Imperial College, Hammersmith Hospital Campus, London, United Kingdom

Vincenzo Libri

v.libri@imperial.ac.uk

Affiliation The National Institute for Health Research (NIHR)-Wellcome Trust Imperial College Clinical Research Facility, Imperial Centre for Translational and Experimental Medicine, Imperial College, Hammersmith Hospital Campus, London, United Kingdom

Competing Interests

Eric W. Jacobson is employed by Sirtris Pharmaceuticals, a GSK Company, Cambridge, MA, USA and Mark Tanner is employed by Imanova Centre of Imaging Sciences, London, UK. The above affiliations do not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DJP VL MRW EWJ. Analyzed the data: DJP VL AE MT. Contributed reagents/materials/analysis tools: DJP EWJ MT AE. Wrote the paper: DJP CS MRW MT VL.