Finite Adaptation and Multistep Moves in the Metropolis-Hastings Algorithm for Variable Selection in Genome-Wide Association Analysis

Tomi Peltola; Pekka Marttinen; Aki Vehtari

doi:10.1371/journal.pone.0049445

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Open Access

Peer-reviewed

Research Article

Finite Adaptation and Multistep Moves in the Metropolis-Hastings Algorithm for Variable Selection in Genome-Wide Association Analysis

Tomi Peltola ,

* E-mail: tomi.peltola@aalto.fi

Affiliation Department of Biomedical Engineering and Computational Science, Aalto University, Espoo, Finland
⨯
Pekka Marttinen,

Affiliation Department of Information and Computer Science, Aalto University, Espoo, Finland
⨯
Aki Vehtari

Affiliation Department of Biomedical Engineering and Computational Science, Aalto University, Espoo, Finland
⨯

Finite Adaptation and Multistep Moves in the Metropolis-Hastings Algorithm for Variable Selection in Genome-Wide Association Analysis

Tomi Peltola,
Pekka Marttinen,
Aki Vehtari

Published: November 15, 2012
https://doi.org/10.1371/journal.pone.0049445

About the Authors

Tomi Peltola

* E-mail: tomi.peltola@aalto.fi

Affiliation Department of Biomedical Engineering and Computational Science, Aalto University, Espoo, Finland

Pekka Marttinen

Affiliation Department of Information and Computer Science, Aalto University, Espoo, Finland

Aki Vehtari

Affiliation Department of Biomedical Engineering and Computational Science, Aalto University, Espoo, Finland

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TP PM AV. Performed the experiments: TP. Analyzed the data: TP. Contributed reagents/materials/analysis tools: TP AV. Wrote the paper: TP PM AV.

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Probability distribution
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Simulation and modeling
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Single nucleotide polymorphisms
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Autocorrelation
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Genome-wide association studies
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Markov models
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Algorithms
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Genetics of disease
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