Ex Vivo Evidence for the Contribution of Hemodynamic Shear Stress Abnormalities to the Early Pathogenesis of Calcific Bicuspid Aortic Valve Disease

Ling Sun; Santanu Chandra; Philippe Sucosky

doi:10.1371/journal.pone.0048843

Loading metrics

Open Access

Peer-reviewed

Research Article

Ex Vivo Evidence for the Contribution of Hemodynamic Shear Stress Abnormalities to the Early Pathogenesis of Calcific Bicuspid Aortic Valve Disease

Ling Sun,

Affiliations Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, Indiana, United States of America, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, United States of America
⨯
Santanu Chandra,

Affiliation Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, Indiana, United States of America
⨯
Philippe Sucosky

* E-mail: Philippe.Sucosky@nd.edu

Affiliations Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, Indiana, United States of America, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, United States of America
⨯

Ex Vivo Evidence for the Contribution of Hemodynamic Shear Stress Abnormalities to the Early Pathogenesis of Calcific Bicuspid Aortic Valve Disease

Ling Sun,
Santanu Chandra,
Philippe Sucosky

Published: October 31, 2012
https://doi.org/10.1371/journal.pone.0048843

About the Authors

Ling Sun

Affiliations Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, Indiana, United States of America, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, United States of America

Santanu Chandra

Affiliation Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, Indiana, United States of America

Philippe Sucosky

* E-mail: Philippe.Sucosky@nd.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LS SC PS. Performed the experiments: LS. Analyzed the data: LS PS. Contributed reagents/materials/analysis tools: LS SC PS. Wrote the paper: LS SC PS. Provided shear stress data to program the bioreactor: SC.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Hemodynamics
Is the Subject Area "Hemodynamics" applicable to this article?

Thanks for your feedback.
Aortic valve
Is the Subject Area "Aortic valve" applicable to this article?

Thanks for your feedback.
Shear stresses
Is the Subject Area "Shear stresses" applicable to this article?

Thanks for your feedback.
Calcification
Is the Subject Area "Calcification" applicable to this article?

Thanks for your feedback.
Immunostaining
Is the Subject Area "Immunostaining" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Osteocalcin
Is the Subject Area "Osteocalcin" applicable to this article?

Thanks for your feedback.
Paracrine signaling
Is the Subject Area "Paracrine signaling" applicable to this article?

Thanks for your feedback.