About the Authors

Sarah Jesse

Contributed equally to this work with: Sarah Jesse, Stefan Lehnert

Affiliation Department of Neurology, University of Ulm, Ulm, Germany

Stefan Lehnert

Contributed equally to this work with: Sarah Jesse, Stefan Lehnert

Affiliation Department of Neurology, University of Ulm, Ulm, Germany

Olaf Jahn

Affiliations Proteomics Group, Max-Planck-Institute for Experimental Medicine, Goettingen, Germany, DFG Research Center for Molecular Physiology of the Brain, Goettingen, Germany

Lucilla Parnetti

Affiliation Department of Neurology, University of Perugia, Perugia, Italy

Hilkka Soininen

Affiliation Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland

Sanna-Kaisa Herukka

Affiliation Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland

Petra Steinacker

Affiliation Department of Neurology, University of Ulm, Ulm, Germany

Saskia Tawfik

Affiliation Department of Neurology, University of Ulm, Ulm, Germany

Hayrettin Tumani

Affiliation Department of Neurology, University of Ulm, Ulm, Germany

Christine A. F. von Arnim

Affiliation Department of Neurology, University of Ulm, Ulm, Germany

Manuela Neumann

Affiliation Institute of Neuropathology, University of Zurich, Zurich, Switzerland

Hans A. Kretzschmar

Affiliation Institute of Neuropathology, Ludwig Maximilians University, Munich, Germany

Hasan Kulaksiz

Affiliation Department of Internal Medicine, University of Ulm, Ulm, Germany

Martin Lenter

Affiliation CNS Diseases Research, Boehringer Ingelheim GmbH & Co. KG, Biberach an der Riss, Germany

Jens Wiltfang

Affiliation Department of Psychiatry, University of Essen-Duisburg, Essen-Duisburg, Germany

Boris Ferger

Affiliation CNS Diseases Research, Boehringer Ingelheim GmbH & Co. KG, Biberach an der Riss, Germany

Bastian Hengerer

Affiliation CNS Diseases Research, Boehringer Ingelheim GmbH & Co. KG, Biberach an der Riss, Germany

Markus Otto

markus.otto@uni-ulm.de

Affiliation Department of Neurology, University of Ulm, Ulm, Germany

Competing Interests

The authors have the following interest: Martin Lenter, Boris Ferger and Bastian Hengerer are employed by CNS Diseases Research, Boehringer Ingelheim GmbH & Co. The rights of the study-data belong to the Landesstiftung Baden-Württemberg (P-LS-Prot/42)as a patent (482-36 US, Attorney Docket No.50818/002001 and 492-37, Attorney Docket No.50818/003001). There are no further products in development or marketed products to declare. This does not alter the authors‚ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MO HT PS. Performed the experiments: SJ SL ST. Analyzed the data: OJ SJS SL. Contributed reagents/materials/analysis tools: LP HS SH CvA MN HAK HK ML JW BF BH. Wrote the paper: SJ SL MO.