About the Authors

Gerwin D. Rodenburg

Affiliation Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands

Elisabeth A. M. Sanders

Affiliation Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands

Elske J. M. van Gils

Affiliations Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands, Linneaus Institute, Spaarne Hospital, Hoofddorp, The Netherlands

Reinier H. Veenhoven

Affiliation Linneaus Institute, Spaarne Hospital, Hoofddorp, The Netherlands

Tomasz Zborowski

Affiliation Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands

Germie P. J. M. van den Dobbelsteen

Affiliation National Institute for Public Health and the Environment, Bilthoven, The Netherlands

Andries C. Bloem

Affiliation Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands

Guy A. M. Berbers

Affiliation National Institute for Public Health and the Environment, Bilthoven, The Netherlands

Debby Bogaert

d.bogaert@umcutrecht.nl

Affiliation Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands

Competing Interests

ES reports receiving unrestricted grants from Pfizer and Baxter for research, consulting fees from Pfizer and GlaxoSmithKline, lecture fees from Pfizer and grant support from Pfizer and GlaxoSmithKline for vaccine studies. RV received research grants for pneumococcal vaccine studies from Pfizer and GSK. DB received consulting fees from Pfizer. For all other authors no potential conflicts reported. The above mentioned grants were not for this specific study. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ES RV DB GvdD GB. Performed the experiments: TZ AB. Analyzed the data: GR EvG. Contributed reagents/materials/analysis tools: AB GB GvdD. Wrote the paper: GR ES EvG RV DB GvdD GB AB.