About the Authors

Joana P. Couto

Affiliations Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Cancer Biology, Porto, Portugal, Faculty of Medicine of the University of Porto, Porto, Portugal

Ana Almeida

Affiliations Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Cancer Biology, Porto, Portugal, Faculty of Medicine of the University of Porto, Porto, Portugal, Institute of Biomedical Sciences Abel Salazar of the University of Porto, Porto, Portugal

Laura Daly

Affiliation Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Manuel Sobrinho-Simões

Affiliations Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Cancer Biology, Porto, Portugal, Faculty of Medicine of the University of Porto, Porto, Portugal, Department of Pathology, Hospital São João, Porto, Portugal

Jacqueline F. Bromberg

psoares@ipatimup.pt (PS); bromberj@mskcc.org (JFB)

Affiliations Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Department of Medicine, Weill Cornell Medical College, New York, New York, United States of America

Paula Soares

psoares@ipatimup.pt (PS); bromberj@mskcc.org (JFB)

Affiliations Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Cancer Biology, Porto, Portugal, Faculty of Medicine of the University of Porto, Porto, Portugal

Competing Interests

Jacqueline Bromberg has received research funding from AstraZeneca. She has had an advisory role at AstraZeneca and Mediummune and received honoria for lectures. There are no patents or products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JPC JFB PS. Performed the experiments: AA LD. Analyzed the data: JPC MSS JFB PS. Contributed reagents/materials/analysis tools: JFB PS. Wrote the paper: JPC JFB PS.