About the Authors

Yumei Wang

Affiliation 5th Medical Department, Section of Endocrinology, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany

Sjoerd Landheer

Affiliation Departments of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Wiek H. van Gilst

Affiliation Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Aart van Amerongen

Affiliation Food and Biobased Research, Wageningen University and Research Center, Wageningen, The Netherlands

Hans-Peter Hammes

Affiliation 5th Medical Department, Section of Endocrinology, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany

Robert H. Henning

Affiliation Departments of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Leo E. Deelman

Affiliation Departments of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Hendrik Buikema

j.h.buikema@umcg.nl

Affiliation Departments of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Competing Interests

Newtricious BV, Oirlo, was a funder for this study. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: WG AA LD HB. Performed the experiments: YW SL LD HB. Analyzed the data: YW SL RH LD HB. Contributed reagents/materials/analysis tools: YW SL AA RH LD HB. Wrote the paper: YW WG HPH LD HB.