About the Authors

Adrian Schwarzer

Contributed equally to this work with: Adrian Schwarzer, Benita Wolf

Affiliation Medical Oncology Immunotherapy Group, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

Benita Wolf

Contributed equally to this work with: Adrian Schwarzer, Benita Wolf

Affiliation Medical Oncology Immunotherapy Group, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

Jan L. Fisher

Affiliations Medical Oncology Immunotherapy Group, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America, Section of Hematology/Oncology, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

Thomas Schwaab

Affiliation Medical Oncology Immunotherapy Group, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

Sven Olek

Affiliation Epiontis GmbH, Berlin, Germany

Udo Baron

Affiliation Epiontis GmbH, Berlin, Germany

Craig R. Tomlinson

Affiliation Department of Pharmacology and Toxicology, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

John D. Seigne

Affiliation Section of Urology, Department of Surgery, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

Nancy A. Crosby

Affiliations Medical Oncology Immunotherapy Group, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America, Section of Hematology/Oncology, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

Jiang Gui

Affiliation Section of Biostatistics and Epidemiology, Department of Family and Community Medicine, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

Thomas H. Hampton

Affiliation Department of Pharmacology and Toxicology, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

Camilo E. Fadul

Affiliations Medical Oncology Immunotherapy Group, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America, Section of Hematology/Oncology, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America, Immunotherapy Program, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America, Department of Neurology, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

John A. Heaney

Affiliation Section of Urology, Department of Surgery, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

Marc S. Ernstoff

Marc.S.Ernstoff@Hitchcock.ORG

Affiliations Medical Oncology Immunotherapy Group, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America, Section of Hematology/Oncology, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America, Immunotherapy Program, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

Competing Interests

Sven Olek and Udo Baron work at Epiontis who did contract testing for this study under a collaborative agreement. The authors received funding from Berlex, Inc. for the clinical trial (Protocol D0238) from which patient samples reported on in this paper originated. This does not alter the authors' adherence to all PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AS BW JLF CEF MSE. Performed the experiments: AS BW JLF SO UB CRT NAC JAH MSE. Analyzed the data: AS BW JLF TS SO UB CRT JDS NAC JG THH CEF JAH MSE. Contributed reagents/materials/analysis tools: SO UB CRT JG THH MSE. Wrote the paper: AS BW JLF MSE.