About the Authors

Jian Luo

Contributed equally to this work with: Jian Luo, Gayathri Swaminath

Affiliation Department of Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America

Gayathri Swaminath

Contributed equally to this work with: Jian Luo, Gayathri Swaminath

Affiliation Department of Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America

Sean P. Brown

Affiliation Department of Therapeutic Discovery, Amgen Inc., South San Francisco, California, United States of America

Jane Zhang

Affiliation Department of Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America

Qi Guo

Affiliation Department of Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America

Michael Chen

Affiliation Department of Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America

Kathy Nguyen

Affiliation Department of Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America

Thanhvien Tran

Affiliation Department of Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America

Lynn Miao

Affiliation Department of Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America

Paul J. Dransfield

Affiliation Department of Therapeutic Discovery, Amgen Inc., South San Francisco, California, United States of America

Marc Vimolratana

Affiliation Department of Therapeutic Discovery, Amgen Inc., South San Francisco, California, United States of America

Jonathan B. Houze

Affiliation Department of Therapeutic Discovery, Amgen Inc., South San Francisco, California, United States of America

Simon Wong

Affiliation Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California, United States of America

Maria Toteva

Affiliation Department of Pharmaceutics, Amgen Inc., South San Francisco, California, United States of America

Bei Shan

Affiliation Department of Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America

Frank Li

Affiliation Department of Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America

Run Zhuang

Affiliation Department of Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America

Daniel C.-H. Lin

dclin@amgen.com

Affiliation Department of Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America

Competing Interests

All authors were employed by and shareholders in Amgen during the study period. Patents filed or issued: U.S. Patent No. 7,649,110, U.S. Patent No. 7,816,367, U.S. Patent No. 8,030,354 and WO 2005/086661. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JL GS SPB PJD SW MT DCHL. Performed the experiments: GS SPB JZ QG MC KN TT LM PJD MV MT FL RZ DCHL. Analyzed the data: JL GS SPB PJD JBH SW MT BS DCHL. Contributed reagents/materials/analysis tools: SPB PJD. Wrote the paper: SPB DCHL.