About the Authors

Saeromi Kim

Contributed equally to this work with: Saeromi Kim, Keun-A Chang

Affiliation Department of Pharmacology, College of Medicine, Neuroscience Research Institute, MRC, Seoul National University, Seoul, South Korea

Keun-A Chang

Contributed equally to this work with: Saeromi Kim, Keun-A Chang

Affiliations Department of Pharmacology, College of Medicine, Neuroscience Research Institute, MRC, Seoul National University, Seoul, South Korea, Department of Pharmacology, Gachon University of Medicine and Science, Incheon, South Korea

Jeong a. Kim

Affiliation Department of Pharmacology, College of Medicine, Neuroscience Research Institute, MRC, Seoul National University, Seoul, South Korea

Hyeong-Geun Park

Affiliation Stem Cell Research Center, RNL Bio Co., Ltd., Seoul, Republic of Korea

Jeong Chan Ra

Affiliation Stem Cell Research Center, RNL Bio Co., Ltd., Seoul, Republic of Korea

Hye-Sun Kim

Affiliation Department of Pharmacology, College of Medicine, Neuroscience Research Institute, MRC, Seoul National University, Seoul, South Korea

Yoo-Hun Suh

yhsuh@snu.ac.kr

Affiliations Department of Pharmacology, College of Medicine, Neuroscience Research Institute, MRC, Seoul National University, Seoul, South Korea, Korea Brain Research Institute (KBRI), Daegu, South Korea

Competing Interests

Jeong Chan Ra and Hyeong Geun Park are employees and shareholders of RNL BIO Limited, which holds patents on some development technologies in this manuscript. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YHS SK KAC. Performed the experiments: SK KAC JAK. Analyzed the data: HSK. Contributed reagents/materials/analysis tools: HGP JCR. Wrote the paper: YHS SK KAC.