About the Authors

Yu-Qiang Liu

Contributed equally to this work with: Yu-Qiang Liu, Fang Qiu

Affiliation Department of Pharmacology, Hubei University of Science and Technology, Xianning, Hubei, P R China

Fang Qiu

Contributed equally to this work with: Yu-Qiang Liu, Fang Qiu

Affiliation Department of Pharmacology, Hubei University of Science and Technology, Xianning, Hubei, P R China

Chun-Yu Qiu

Affiliation Department of Pharmacology, Hubei University of Science and Technology, Xianning, Hubei, P R China

Qi Cai

Affiliation Department of Pharmacology, Hubei University of Science and Technology, Xianning, Hubei, P R China

Pengcheng Zou

Affiliation Hubei Furen Pharmaceutical Corporation Ltd, Shinanqiao, Tongcheng, Hubei, P R China

Heming Wu

Affiliation Hubei Furen Pharmaceutical Corporation Ltd, Shinanqiao, Tongcheng, Hubei, P R China

Wang-Ping Hu

wangping_hu@yahoo.com

Affiliation Department of Pharmacology, Hubei University of Science and Technology, Xianning, Hubei, P R China

Competing Interests

PZ and HW are employed by a commercial company, Hubei Furen Pharmaceutical Corporation Ltd. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials. The authors and Hubei Furen Pharmaceutical Corporation Ltd. have also declared that no competing interests relating to employment, consultancy, patents, products in development or marketed products etc. exist.

Author Contributions

Conceived and designed the experiments: Y-QL FQ W-PH. Performed the experiments: Y-QL FQ C-YQ QC PZ HW. Analyzed the data: Y-QL FQ. Wrote the paper: Y-QL FQ W-PH.