Structural Basis for the dsRNA Specificity of the Lassa Virus NP Exonuclease

Kathryn M. Hastie; Liam B. King; Michelle A. Zandonatti; Erica Ollmann Saphire

doi:10.1371/journal.pone.0044211

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Open Access

Peer-reviewed

Research Article

Structural Basis for the dsRNA Specificity of the Lassa Virus NP Exonuclease

Kathryn M. Hastie,

Affiliation Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Liam B. King,

Affiliation Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Michelle A. Zandonatti,

Affiliation Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Erica Ollmann Saphire

* E-mail: erica@scripps.edu

Affiliations Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America
⨯

Structural Basis for the dsRNA Specificity of the Lassa Virus NP Exonuclease

Kathryn M. Hastie,
Liam B. King,
Michelle A. Zandonatti,
Erica Ollmann Saphire

Published: August 28, 2012
https://doi.org/10.1371/journal.pone.0044211

About the Authors

Kathryn M. Hastie

Affiliation Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

Liam B. King

Affiliation Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

Michelle A. Zandonatti

Affiliation Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

Erica Ollmann Saphire

* E-mail: erica@scripps.edu

Affiliations Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KMH LBK EOS. Performed the experiments: KMH LBK MAZ. Analyzed the data: KMH LMK EOS. Contributed reagents/materials/analysis tools: KMH MAZ EOS. Wrote the paper: KMH EOS.

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RNA structure
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Alanine
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Mutation
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Crystal structure
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Nucleotides
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Double stranded RNA
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Hydrogen bonding
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Point mutation
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