About the Authors

Christiaan H. Vinkers

c.h.vinkers@uu.nl

Affiliations Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands, Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

Ruud van Oorschot

Affiliation Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

Elsebet Ø. Nielsen

Affiliation NeuroSearch A/S, NsDiscovery, Ballerup, Denmark

James M. Cook

Affiliation Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, United States of America

Henrik H. Hansen

Affiliations NeuroSearch A/S, NsDiscovery, Ballerup, Denmark, Gubra ApS, Hørsholm, Denmark

Lucianne Groenink

Affiliation Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

Berend Olivier

Affiliations Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America

Naheed R. Mirza

Affiliations NeuroSearch A/S, NsDiscovery, Ballerup, Denmark, Aniona ApS, Ballerup, Denmark

Competing Interests

HHH, EON and NRM are employees of NeuroSearch A/S. This does not alter the authors′ adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CHV EON HEH JMC LG BO NRM. Performed the experiments: CHV RVO EON HEH. Analyzed the data: CHV HEH EON. Contributed reagents/materials/analysis tools: JMC. Wrote the paper: CHV EON JMC HEH LG BO NRM.