Effects of Niacin Restriction on Sirtuin and PARP Responses to Photodamage in Human Skin

Claudia A. Benavente; Stephanie A. Schnell; Elaine L. Jacobson

doi:10.1371/journal.pone.0042276

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Open Access

Peer-reviewed

Research Article

Effects of Niacin Restriction on Sirtuin and PARP Responses to Photodamage in Human Skin

Claudia A. Benavente,

Affiliation Arizona Cancer Center and Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona, United States of America
⨯
Stephanie A. Schnell,

Affiliation Arizona Cancer Center and Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona, United States of America
⨯
Elaine L. Jacobson

* E-mail: elaine.jacobson@pharmacy.arizona.edu

Affiliation Arizona Cancer Center and Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona, United States of America
⨯

Effects of Niacin Restriction on Sirtuin and PARP Responses to Photodamage in Human Skin

Claudia A. Benavente,
Stephanie A. Schnell,
Elaine L. Jacobson

Published: July 31, 2012
https://doi.org/10.1371/journal.pone.0042276

About the Authors

Claudia A. Benavente

Affiliation Arizona Cancer Center and Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona, United States of America

Stephanie A. Schnell

Affiliation Arizona Cancer Center and Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona, United States of America

Elaine L. Jacobson

* E-mail: elaine.jacobson@pharmacy.arizona.edu

Affiliation Arizona Cancer Center and Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CAB ELJ. Performed the experiments: CAB SAS. Analyzed the data: CAB. Contributed reagents/materials/analysis tools: ELJ. Wrote the paper: CAB ELJ.

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Niacin
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Gene expression
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Keratinocytes
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Oxidative stress
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DNA damage
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Cellular stress responses
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Protein expression
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Skin tumors
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