NMR Structure of Hsp12, a Protein Induced by and Required for Dietary Restriction-Induced Lifespan Extension in Yeast

Andrew P. Herbert; Michèle Riesen; Leanne Bloxam; Effie Kosmidou; Brian M. Wareing; James R. Johnson; Marie M. Phelan; Stephen R. Pennington; Lu-Yun Lian; Alan Morgan

doi:10.1371/journal.pone.0041975

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Open Access

Peer-reviewed

Research Article

NMR Structure of Hsp12, a Protein Induced by and Required for Dietary Restriction-Induced Lifespan Extension in Yeast

Andrew P. Herbert ,

Contributed equally to this work with: Andrew P. Herbert, Michèle Riesen

Affiliations Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom, NMR Centre for Structural Biology, Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom
⨯
Michèle Riesen ,

Contributed equally to this work with: Andrew P. Herbert, Michèle Riesen

Affiliation Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
⨯
Leanne Bloxam,

Affiliation Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
⨯
Effie Kosmidou,

Affiliation Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
⨯
Brian M. Wareing,

Affiliation Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
⨯
James R. Johnson,

Affiliation Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
⨯
Marie M. Phelan,

Affiliation NMR Centre for Structural Biology, Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom
⨯
Stephen R. Pennington,

Affiliation University College Dublin Conway Institute of Biomedical and Biomolecular Research, University College Dublin, Dublin, Ireland
⨯
Lu-Yun Lian,

Affiliation NMR Centre for Structural Biology, Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom
⨯
Alan Morgan

* E-mail: amorgan@liverpool.ac.uk

Affiliation Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
⨯

NMR Structure of Hsp12, a Protein Induced by and Required for Dietary Restriction-Induced Lifespan Extension in Yeast

Andrew P. Herbert,
Michèle Riesen,
Leanne Bloxam,
Effie Kosmidou,
Brian M. Wareing,
James R. Johnson,
Marie M. Phelan,
Stephen R. Pennington,
Lu-Yun Lian,
Alan Morgan

Published: July 27, 2012
https://doi.org/10.1371/journal.pone.0041975

About the Authors

Andrew P. Herbert

Contributed equally to this work with: Andrew P. Herbert, Michèle Riesen

Affiliations Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom, NMR Centre for Structural Biology, Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom

Michèle Riesen

Contributed equally to this work with: Andrew P. Herbert, Michèle Riesen

Affiliation Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom

Leanne Bloxam

Affiliation Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom

Effie Kosmidou

Affiliation Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom

Brian M. Wareing

Affiliation Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom

James R. Johnson

Affiliation Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom

Marie M. Phelan

Affiliation NMR Centre for Structural Biology, Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom

Stephen R. Pennington

Affiliation University College Dublin Conway Institute of Biomedical and Biomolecular Research, University College Dublin, Dublin, Ireland

Lu-Yun Lian

Affiliation NMR Centre for Structural Biology, Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom

Alan Morgan

* E-mail: amorgan@liverpool.ac.uk

Affiliation Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

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Glucose
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Yeast
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Recombinant proteins
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Insulin
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Gel electrophoresis
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Aging
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Heat shock response
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Saccharomyces cerevisiae
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