About the Authors

Katie Harron

Affiliation MRC Centre for Epidemiology of Child Health, Institute of Child Health, University College London, London, United Kingdom

Twin Lee

Affiliation Paediatric Intensive Care Unit, Great Ormond Street Hospital, London, United Kingdom

Tracy Ball

Affiliation Clinical Trials Research Centre, University of Liverpool, Liverpool, United Kingdom

Quen Mok

Affiliation Paediatric Intensive Care Unit, Great Ormond Street Hospital, London, United Kingdom

Carrol Gamble

Affiliation Clinical Trials Research Centre, University of Liverpool, Liverpool, United Kingdom

Duncan Macrae

Affiliation Paediatric Intensive Care Unit, Royal Brompton Hospital, London, United Kingdom

Ruth Gilbert

R.Gilbert@ucl.ac.uk

Affiliation MRC Centre for Epidemiology of Child Health, Institute of Child Health, University College London, London, United Kingdom

on behalf of CATCH. team

Membership of the CATCH team is provided in the Acknowledgments

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RG KH CG TB QM. Performed the experiments: TL. Analyzed the data: KH. Contributed reagents/materials/analysis tools: DM CG TL QM TB. Wrote the paper: KH RG TL TB QM DM CG.