Temporal Separation of Aggregation and Ubiquitination during Early Inclusion Formation in Transgenic Mice Carrying the Huntington’s Disease Mutation

Belvin Gong; Catherine Kielar; A. Jennifer Morton

doi:10.1371/journal.pone.0041450

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Open Access

Peer-reviewed

Research Article

Temporal Separation of Aggregation and Ubiquitination during Early Inclusion Formation in Transgenic Mice Carrying the Huntington’s Disease Mutation

Belvin Gong ,

Contributed equally to this work with: Belvin Gong, Catherine Kielar

Affiliations Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom, UC Davis/NIH NeuroMab Facility, Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, California, United States of America
⨯
Catherine Kielar ,

Contributed equally to this work with: Belvin Gong, Catherine Kielar

Affiliation Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom
⨯
A. Jennifer Morton

* E-mail: ajm41@cam.ac.uk

Affiliation Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom
⨯

Temporal Separation of Aggregation and Ubiquitination during Early Inclusion Formation in Transgenic Mice Carrying the Huntington’s Disease Mutation

Belvin Gong,
Catherine Kielar,
A. Jennifer Morton

Published: July 24, 2012
https://doi.org/10.1371/journal.pone.0041450

About the Authors

Belvin Gong

Contributed equally to this work with: Belvin Gong, Catherine Kielar

Affiliations Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom, UC Davis/NIH NeuroMab Facility, Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, California, United States of America

Catherine Kielar

Contributed equally to this work with: Belvin Gong, Catherine Kielar

Affiliation Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom

A. Jennifer Morton

* E-mail: ajm41@cam.ac.uk

Affiliation Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom

Competing Interests

This study was supported by Merck, Sharp and Dohme. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: AJM BG. Performed the experiments: BG. Analyzed the data: BG CK AJM. Contributed reagents/materials/analysis tools: AJM. Wrote the paper: BG CK AJM. Re-designed and re-did the figures for the manuscript: CK.

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Neurons
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Ubiquitination
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Genetically modified animals
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Mouse models
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Nucleation
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Huntington disease
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Immunohistochemistry techniques
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Neostriatum
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