About the Authors

Kazunori Shimizu

kshimizu@pharm.kyoto-u.ac.jp (KS); konishi@se.ritsumei.ac.jp (S. Konishi)

Affiliations Institute for Innovative NanoBio Drug Discovery and Development, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan, Ritsumeikan-Global Innovation Research Organization, Ritsumeikan University, Kusatsu, Shiga, Japan

Shigeru Kawakami

Affiliation Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan

Kouji Hayashi

Affiliation Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan

Hideyuki Kinoshita

Affiliation Department of Medicine and Clinical Science, School of Medicine, Kyoto University Graduate, Kyoto, Japan

Koichiro Kuwahara

Affiliation Department of Medicine and Clinical Science, School of Medicine, Kyoto University Graduate, Kyoto, Japan

Kazuwa Nakao

Affiliation Department of Medicine and Clinical Science, School of Medicine, Kyoto University Graduate, Kyoto, Japan

Mitsuru Hashida

Affiliations Institute for Innovative NanoBio Drug Discovery and Development, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan, Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan, Institute for Integrated Cell-Material Sciences, Kyoto University, Kyoto, Japan

Satoshi Konishi

kshimizu@pharm.kyoto-u.ac.jp (KS); konishi@se.ritsumei.ac.jp (S. Konishi)

Affiliations Institute for Innovative NanoBio Drug Discovery and Development, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan, Ritsumeikan-Global Innovation Research Organization, Ritsumeikan University, Kusatsu, Shiga, Japan, Department of Micro System Technology, Ritsumeikan University, Kusatsu, Shiga, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: Kazunori Shimizu, Shigeru Kawakami, Kouji Hayashi, Hideyuki Kinoshita, Koichiro Kuwahara, Kazuwa Nakao, Mitsuru Hashida, Satoshi Konishi. Performed the experiments: Kazunori Shimizu, Shigeru Kawakami, Kouji Hayashi, Hideyuki Kinoshita. Analyzed the data: Kazunori Shimizu, Shigeru Kawakami, Kouji Hayashi. Contributed reagents/materials/analysis tools: Wrote the manuscript: Kazunori Shimizu, Shigeru Kawakami, Kouji Hayashi.