About the Authors
- Lynley D. Pound
-
Affiliation Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee, United States of America
- Suparna A. Sarkar
-
Affiliation Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, Colorado, United States of America
- Alessandro Ustione
-
Affiliation Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee, United States of America
- Prasanna K. Dadi
-
Affiliation Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee, United States of America
- Melanie K. Shadoan
-
Affiliation Lexicon Pharmaceuticals Incorporated, The Woodlands, Texas, United States of America
- Catherine E. Lee
-
Affiliation Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, Colorado, United States of America
- Jay A. Walters
-
Affiliation Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, Colorado, United States of America
- Masakazu Shiota
-
Affiliation Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee, United States of America
- Owen P. McGuinness
-
Affiliation Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee, United States of America
- David A. Jacobson
-
Affiliation Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee, United States of America
- David W. Piston
-
Affiliation Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee, United States of America
- John C. Hutton
-
Affiliation Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, Colorado, United States of America
- David R. Powell
-
Affiliation Lexicon Pharmaceuticals Incorporated, The Woodlands, Texas, United States of America
- Richard M. O’Brien
-
* E-mail: richard.obrien@vanderbilt.edu
Affiliation Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee, United States of America
Competing Interests
MKS and DRP work for Lexicon Pharmaceuticals and generated the mice described in this study. There are no pending patents, products in development or marketed products associated with these mice or this study. This relationship between Lexicon and Vanderbilt does not alter the authors’ adherence to all the PLoS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: LDP SAS AU MS OPM DAJ DWP JCH DRP RO. Performed the experiments: LDP SAS AU PKD MKS CEL JAW MS DAJ RO. Analyzed the data: LDP SAS AU MS OPM DAJ DWP JCH DRP RO. Contributed reagents/materials/analysis tools: MKS JAW DRP. Wrote the paper: LDP SAS AU OPM DAJ DWP JCH DRP RO.