A Dual Polybasic Motif Determines Phosphoinositide Binding and Regulation in the P2X Channel Family

Louis-Philippe Bernier; Dominique Blais; Éric Boué-Grabot; Philippe Séguéla

doi:10.1371/journal.pone.0040595

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Open Access

Peer-reviewed

Research Article

A Dual Polybasic Motif Determines Phosphoinositide Binding and Regulation in the P2X Channel Family

Louis-Philippe Bernier,

Affiliation Department of Neurology and Neurosurgery, Montreal Neurological Institute, Alan Edwards Centre for Research on Pain, McGill University, Montréal, Québec, Canada
⨯
Dominique Blais,

Affiliation Department of Neurology and Neurosurgery, Montreal Neurological Institute, Alan Edwards Centre for Research on Pain, McGill University, Montréal, Québec, Canada
⨯
Éric Boué-Grabot,

Affiliation Institut des Maladies Neurodégénératives, Université Bordeaux Segalen, CNRS UMR 5293, Bordeaux, France
⨯
Philippe Séguéla

* E-mail: philippe.seguela@mcgill.ca

Affiliation Department of Neurology and Neurosurgery, Montreal Neurological Institute, Alan Edwards Centre for Research on Pain, McGill University, Montréal, Québec, Canada
⨯

A Dual Polybasic Motif Determines Phosphoinositide Binding and Regulation in the P2X Channel Family

Louis-Philippe Bernier,
Dominique Blais,
Éric Boué-Grabot,
Philippe Séguéla

Published: July 11, 2012
https://doi.org/10.1371/journal.pone.0040595

About the Authors

Louis-Philippe Bernier

Affiliation Department of Neurology and Neurosurgery, Montreal Neurological Institute, Alan Edwards Centre for Research on Pain, McGill University, Montréal, Québec, Canada

Dominique Blais

Affiliation Department of Neurology and Neurosurgery, Montreal Neurological Institute, Alan Edwards Centre for Research on Pain, McGill University, Montréal, Québec, Canada

Éric Boué-Grabot

Affiliation Institut des Maladies Neurodégénératives, Université Bordeaux Segalen, CNRS UMR 5293, Bordeaux, France

Philippe Séguéla

* E-mail: philippe.seguela@mcgill.ca

Affiliation Department of Neurology and Neurosurgery, Montreal Neurological Institute, Alan Edwards Centre for Research on Pain, McGill University, Montréal, Québec, Canada

Competing Interests

The authors declare that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LPB EBG PS. Performed the experiments: LPB DB. Analyzed the data: LPB EBG PS. Contributed reagents/materials/analysis tools: PS. Wrote the paper: LPB EBG PS.

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Binding analysis
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Lysine
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Transient receptor potential channels
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Xenopus oocytes
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Intracellular receptors
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Phospholipids
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Cell membranes
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Ion channels
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