About the Authors

Caterina Vacchi-Suzzi

Affiliation Discovery and Investigative Safety, Novartis Institutes for Biomedical Research, Basel, Switzerland

Yasmina Bauer

Affiliation Translational Science Biology, Actelion Pharmaceuticals Ltd, Allschwil, Switzerland

Brian R. Berridge

Affiliation Safety Assessment, GlaxoSmithKline, Research Triangle Park, North Carolina, United States of America

Sandrine Bongiovanni

Affiliation Biomarker Development, Novartis Institutes for Biomedical Research, Basel, Switzerland

Kevin Gerrish

Affiliation National Institute of Environmental Health Science, National Institutes of Health, Research Triangle Park, North Carolina, United States of America

Hisham K. Hamadeh

Affiliation Comparative Biology and Safety Sciences, Amgen Inc., Thousand Oaks, California, United States of America

Martin Letzkus

Affiliation Biomarker Development, Novartis Institutes for Biomedical Research, Basel, Switzerland

Jonathan Lyon

Affiliation Investigative Preclinical Toxicology, GlaxoSmithKline, Ware, United Kingdom

Jonathan Moggs

Affiliation Discovery and Investigative Safety, Novartis Institutes for Biomedical Research, Basel, Switzerland

Richard S. Paules

Affiliation National Institute of Environmental Health Science, National Institutes of Health, Research Triangle Park, North Carolina, United States of America

François Pognan

Affiliation Discovery and Investigative Safety, Novartis Institutes for Biomedical Research, Basel, Switzerland

Frank Staedtler

Affiliation Biomarker Development, Novartis Institutes for Biomedical Research, Basel, Switzerland

Martin P. Vidgeon-Hart

Affiliation Investigative Preclinical Toxicology, GlaxoSmithKline, Ware, United Kingdom

Olivier Grenet

Affiliation Discovery and Investigative Safety, Novartis Institutes for Biomedical Research, Basel, Switzerland

Philippe Couttet

philippe.couttet@novartis.com

Affiliation Discovery and Investigative Safety, Novartis Institutes for Biomedical Research, Basel, Switzerland

Competing Interests

The authors have read the journal’s policy and have the following conflicts: Authors Dr. Vacchi-Suzzi, Dr. Moggs, Dr. Pognan, Dr. Grenet, Dr. Couttet, Dr. Bongiovanni, Dr. Letzkus and Dr. Staedtler are employed by Novartis Institutes for Biomedical Research. Dr. Bauer is employed by Actelion Pharmaceuticals Ltd. Dr. Berridge, Dr. Lyon and Dr. Vidgeon-Hart are employed by GlaxoSmithKline. Dr. Hamadeh is employed by Amgen Inc. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: HH JL RP PC CVS. Performed the experiments: BRB ML MPV-H CVS. Analyzed the data: YB KG HH CVS. Contributed reagents/materials/analysis tools: SB FS. Wrote the paper: CVS KG PC. Supervised the study and experimental design, helped interpretation of the data: CVS PC JM OG FP YB KG HH JL RP NH FS. Reviewed and commented on the manuscript: CVS YB BRB SB KG HH ML JL JM RP FP FS MPV-H OG PC.