About the Authors

J. Christopher States

jcstates@louisville.edu

Affiliations Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky, United States of America, Center for Environmental Genomics and Integrative Biology, University of Louisville, Louisville, Kentucky, United States of America, Center for Genetics and Molecular Medicine, University of Louisville, Louisville, Kentucky, United States of America

Amar V. Singh

Current address: Syngenta, Research Triangle Park, North Carolina, United States of America

Affiliations Center for Environmental Genomics and Integrative Biology, University of Louisville, Louisville, Kentucky, United States of America, Department of Molecular, Cellular and Craniofacial Biology, University of Louisville, Louisville, Kentucky, United States of America

Thomas B. Knudsen

Current address: Environmental Protection Agency, National Center for Computational Toxicology, Research Triangle Park, North Carolina, United States of America

Affiliations Center for Environmental Genomics and Integrative Biology, University of Louisville, Louisville, Kentucky, United States of America, Center for Genetics and Molecular Medicine, University of Louisville, Louisville, Kentucky, United States of America, Department of Molecular, Cellular and Craniofacial Biology, University of Louisville, Louisville, Kentucky, United States of America

Eric C. Rouchka

Affiliations Center for Environmental Genomics and Integrative Biology, University of Louisville, Louisville, Kentucky, United States of America, Center for Genetics and Molecular Medicine, University of Louisville, Louisville, Kentucky, United States of America, Department of Computer Engineering and Computer Science, University of Louisville, Louisville, Kentucky, United States of America

Ntube O. Ngalame

Current address: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America

Affiliation Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky, United States of America

Gavin E. Arteel

Affiliations Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky, United States of America, Center for Environmental Genomics and Integrative Biology, University of Louisville, Louisville, Kentucky, United States of America, Center for Genetics and Molecular Medicine, University of Louisville, Louisville, Kentucky, United States of America

Yulan Piao

Affiliation Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, United States of America

Minoru S. H. Ko

Affiliation Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, United States of America

Competing Interests

The authors declare the following interest: co-author J. Christopher States is a PLoS ONE Editorial Board member. This does not alter the authors’ adherence to all the PLoS ONE policies on sharing data and materials. The authors have declared that no other competing interests exist.

Author Contributions

Conceived and designed the experiments: JCS TBK NON GEA. Performed the experiments: NON YP MSHK. Analyzed the data: JCS AVS TBK ECR NON GEA YP MSHK. Contributed reagents/materials/analysis tools: JCS AVS TBK ECR GEA MSHK. Wrote the paper: JCS AVS TBK ECR NON GEA YP MSHK.