About the Authors

Barbara B. Bendlin

bbb@medicine.wisc.edu

Affiliations Geriatric Research, Education and Clinical Center (GRECC), William S. Middleton Memorial Veteran’s Hospital, Madison, Wisconsin, United States of America, Wisconsin Alzheimer’s Disease Research Center, Department of Medicine, University of Wisconsin, Madison, Wisconsin, United States of America

Cynthia M. Carlsson

Affiliations Geriatric Research, Education and Clinical Center (GRECC), William S. Middleton Memorial Veteran’s Hospital, Madison, Wisconsin, United States of America, Wisconsin Alzheimer’s Disease Research Center, Department of Medicine, University of Wisconsin, Madison, Wisconsin, United States of America

Sterling C. Johnson

Affiliations Geriatric Research, Education and Clinical Center (GRECC), William S. Middleton Memorial Veteran’s Hospital, Madison, Wisconsin, United States of America, Wisconsin Alzheimer’s Disease Research Center, Department of Medicine, University of Wisconsin, Madison, Wisconsin, United States of America

Henrik Zetterberg

Affiliation Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Sweden

Kaj Blennow

Affiliation Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Sweden

Auriel A. Willette

Affiliations Geriatric Research, Education and Clinical Center (GRECC), William S. Middleton Memorial Veteran’s Hospital, Madison, Wisconsin, United States of America, Wisconsin Alzheimer’s Disease Research Center, Department of Medicine, University of Wisconsin, Madison, Wisconsin, United States of America

Ozioma C. Okonkwo

Affiliations Geriatric Research, Education and Clinical Center (GRECC), William S. Middleton Memorial Veteran’s Hospital, Madison, Wisconsin, United States of America, Wisconsin Alzheimer’s Disease Research Center, Department of Medicine, University of Wisconsin, Madison, Wisconsin, United States of America

Aparna Sodhi

Affiliations Geriatric Research, Education and Clinical Center (GRECC), William S. Middleton Memorial Veteran’s Hospital, Madison, Wisconsin, United States of America, Wisconsin Alzheimer’s Disease Research Center, Department of Medicine, University of Wisconsin, Madison, Wisconsin, United States of America

Michele L. Ries

Affiliations Geriatric Research, Education and Clinical Center (GRECC), William S. Middleton Memorial Veteran’s Hospital, Madison, Wisconsin, United States of America, Wisconsin Alzheimer’s Disease Research Center, Department of Medicine, University of Wisconsin, Madison, Wisconsin, United States of America

Alex C. Birdsill

Affiliations Geriatric Research, Education and Clinical Center (GRECC), William S. Middleton Memorial Veteran’s Hospital, Madison, Wisconsin, United States of America, Wisconsin Alzheimer’s Disease Research Center, Department of Medicine, University of Wisconsin, Madison, Wisconsin, United States of America

Andrew L. Alexander

Affiliations University of Wisconsin School of Medicine and Public Health, Department of Medical Physics, Madison, Wisconsin, United States of America, University of Wisconsin School of Medicine and Public Health, Department of Psychiatry, Madison, Wisconsin, United States of America, Waisman Laboratory for Brain Imaging and Behavior, Madison, Wisconsin, United States of America

Howard A. Rowley

Affiliation University of Wisconsin School of Medicine and Public Health, Department of Radiology, Madison, Wisconsin, United States of America

Luigi Puglielli

Affiliations Geriatric Research, Education and Clinical Center (GRECC), William S. Middleton Memorial Veteran’s Hospital, Madison, Wisconsin, United States of America, Wisconsin Alzheimer’s Disease Research Center, Department of Medicine, University of Wisconsin, Madison, Wisconsin, United States of America

Sanjay Asthana

Affiliations Geriatric Research, Education and Clinical Center (GRECC), William S. Middleton Memorial Veteran’s Hospital, Madison, Wisconsin, United States of America, Wisconsin Alzheimer’s Disease Research Center, Department of Medicine, University of Wisconsin, Madison, Wisconsin, United States of America

Mark A. Sager

Affiliations Geriatric Research, Education and Clinical Center (GRECC), William S. Middleton Memorial Veteran’s Hospital, Madison, Wisconsin, United States of America, Wisconsin Alzheimer’s Disease Research Center, Department of Medicine, University of Wisconsin, Madison, Wisconsin, United States of America

Competing Interests

Dr. Blennow has served on scientific advisory boards for Adlyfe Inc., Bayer Schering Pharma, Bristol-Myers Squibb, and Merz Pharmaceuticals GmbH; received a speaker honorarium from Pfizer Inc.; serves as a consultant for Wyeth, AstraZeneca, Bristol-Myers Squibb, and Eli Lilly and Company; and has received research support from Pfizer Inc., Innogenetics, the Swedish Research Council, Västra Götalandsregionen, Sweden, the Swedish Brain Power Project, the Swedish Council for Working Life and Social Research, the Swedish Alzheimer Foundation, Stiftelsen för Gamla Tjänarinnor, and the King Gustaf V and Queen Victoria Foundation. Dr. Zetterberg has served on a scientific advisory board for GlaxoSmithKline; serves as an Associate Editor for the Journal of Alzheimer’s Disease; and receives research support from the Swedish Research Council, the Alzheimer’s Association, and the Royal Swedish Academy of Sciences. This does not alter the authors′ adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: BBB CMC LP. Performed the experiments: BBB CMC HZ KB AAW MLR ALA HAR SA MAS. Analyzed the data: BBB CMC HZ KB AAW ACB MLR AS ALA SCJ. Contributed reagents/materials/analysis tools: HZ KB ALA. Wrote the paper: BBB CMC SCJ HZ KB AAW OCO AS MLR ACB ALA HAR LP SA MAS.