About the Authors

Yasuyuki Tomita

Affiliations Central Laboratories for Frontier Technology, KIRIN Holdings Company, Ltd., Yokohama, Kanagawa, Japan, Center for Information Biology and DNA Data Bank of Japan, National Institute of Genetics, Mishima, Shizuoka, Japan

Kazuho Ikeo

Affiliation Center for Information Biology and DNA Data Bank of Japan, National Institute of Genetics, Mishima, Shizuoka, Japan

Hideyuki Tamakawa

Affiliation Central Laboratories for Frontier Technology, KIRIN Holdings Company, Ltd., Yokohama, Kanagawa, Japan

Takashi Gojobori

Affiliation Center for Information Biology and DNA Data Bank of Japan, National Institute of Genetics, Mishima, Shizuoka, Japan

Shigehito Ikushima

Shigehito_Ikushima@kirin.co.jp

Affiliation Central Laboratories for Frontier Technology, KIRIN Holdings Company, Ltd., Yokohama, Kanagawa, Japan

Competing Interests

Tomita and Ikushima are members of Central Laboratories for Frontier Technology, KIRIN Holdings Company, Ltd. and employees in this company. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SI. Performed the experiments: YT SI. Analyzed the data: YT HT SI. Contributed reagents/materials/analysis tools: KI TG. Wrote the paper: YT TG SI.