About the Authors

Ph. Gabriel Steg

gabriel.steg@bch.ap-hop-paris.fr

Affiliations INSERM U698, Paris, France, Université Paris Diderot, Paris, France, AP-HP, Hôpital Bichat, Paris, France

Roberto Ferrari

Affiliation Department of Cardiology and LTTA Centre, University of Ferrara, Salvatore Maugeri Foundation, IRCCS, Lumezzan, Italy

Ian Ford

Affiliation University of Glasgow, Glasgow, United Kingdom

Nicola Greenlaw

Affiliation University of Glasgow, Glasgow, United Kingdom

Jean-Claude Tardif

Affiliation Montreal Heart Institute, Université de Montreal, Montreal, Canada

Michal Tendera

Affiliation Medical University of Silesia, Katowice, Poland

Hélène Abergel

Affiliations INSERM U698, Paris, France, Université Paris Diderot, Paris, France, AP-HP, Hôpital Bichat, Paris, France

Kim M. Fox

Affiliation NHLI Imperial College, ICMS, Royal Brompton Hospital, London, United Kingdom

for the CLARIFY Investigators

For a full list of the CLARIFY investigators please see Appendix S1.

Competing Interests

The authors have read the journal's policy and have the following conflicts: This study was supported by research grants from Servier, France. PGS: has received research grants from Servier; consultancy fees/honoraria from Amgen, Astellas, AstraZeneca, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Daiichi Sankyo/Eli Lilly alliance, Eisai, GlaxoSmithKline, Medtronic, Merck Sharpe and Dohme, Pfizer, Roche, sanofi-aventis, Servier, and The Medicines Company; and has equity ownership in Aterovax. RF: Speaker's bureau: Servier, Roche and Boehringer Ingelheim; Research Grant: Servier, Boehringer Ingelheim and Roche; Advisory Board: Servier, Bayer, Roche and Boehringer Ingelheim. IF: Research grants, honoraria for committee membership, and support for conference attendance from Servier. NG: none. J-CT: Research grants and honoraria from Servier. MT: Fees, honoraria, and research grants from Amgen, Bayer, Menarini, Servier and TIMI Group. HA: none. KMF: Fees, honoraria, and research grants from Servier. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: PGS RF IF KMF J-CT MT. Performed the experiments: HA IF NG. Analyzed the data: IF NG. Wrote the paper: HA RF IF KMF NG J-CT MT. Wrote the first draft of the manuscript: PGS.