About the Authors

Rachel P. J. Lai

Affiliation Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom

Michael S. Seaman

Affiliation Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

Paul Tonks

Affiliation Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom

Frank Wegmann

Affiliation The Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom

David J. Seilly

Affiliation Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom

Simon D. W. Frost

Affiliation Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom

Celia C. LaBranche

Affiliation Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America

David C. Montefiori

Affiliation Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America

Antu K. Dey

Affiliation Novartis Vaccines and Diagnostics Inc., Massachusetts, United States of America

Indresh K. Srivastava

Current address: Vaccine Production Program Laboratory, Vaccine Research Center, NIAID/NIH, Gaithersburg, Maryland, United States of America

Affiliation Novartis Vaccines and Diagnostics Inc., Massachusetts, United States of America

Quentin Sattentau

Affiliation The Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom

Susan W. Barnett

Affiliation Novartis Vaccines and Diagnostics Inc., Massachusetts, United States of America

Jonathan L. Heeney

jlh66@cam.ac.uk

Affiliation Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom

Competing Interests

AKD and SWB are employees at Novartis Vaccines & Diagnostics (NVD). SWB is a shareholder of NVD. MF59 is a patented adjuvant of NVD. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: RPJL IKS QS SWB JLH. Performed the experiments: RPJL PT FW DJS AKD. Analyzed the data: RPJL MSS SDWF CCL DCM. Contributed reagents/materials/analysis tools: MSS SDWF CCL DCM AKD IKS QS SWB. Wrote the paper: RPJL JLH.