About the Authors

Lyndsey E. Shorey

Affiliations Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon, United States of America, Linus Pauling Institute, Oregon State University, Corvallis, Oregon, United States of America

Amanda M. Hagman

Affiliation Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, Utah, United States of America

David E. Williams

Affiliations Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon, United States of America, Linus Pauling Institute, Oregon State University, Corvallis, Oregon, United States of America

Emily Ho

Affiliations Linus Pauling Institute, Oregon State University, Corvallis, Oregon, United States of America, Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, Oregon, United States of America

Roderick H. Dashwood

Affiliations Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon, United States of America, Linus Pauling Institute, Oregon State University, Corvallis, Oregon, United States of America

Abby D. Benninghoff

abby.benninghoff@usu.edu

Affiliations Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, Utah, United States of America, School of Veterinary Medicine, Utah State University, Logan, Utah, United States of America, The Utah Science Technology and Research Applied Nutrition Research, Utah State University, Logan, Utah, United States of America

Competing Interests

BioResponse Nutrients, LLC donated the DIM formulation used in this study, BioResponse-DIM. The monetary value of this donation is less than $500. BioResponse Nutrients, LLC did not have any involvement in the experiment design, execution, analysis or composition of this manuscript. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. USANA Health Sciences provided financial support for this research, via its support of the Linus Pauling Institute and associated laboratories. USANA did not have any involvement in the experiment design, execution, analysis or composition of this manuscript. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: LS DW AB. Performed the experiments: LS AH AB. Analyzed the data: LS AB. Contributed reagents/materials/analysis tools: DW RD EH AB. Wrote the paper: LS AB. Manuscript review: RD EH DW.