About the Authors

Jacqueline N. Milton

Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

Paola Sebastiani

Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

Nadia Solovieff

Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

Stephen W. Hartley

Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

Pallav Bhatnagar

Affiliation McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Dan E. Arking

Affiliation McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Daniel A. Dworkis

Affiliation Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America

James F. Casella

Affiliation Department of Pediatrics, Division of Pediatric Hematology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Emily Barron-Casella

Affiliation Department of Pediatrics, Division of Pediatric Hematology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Christopher J. Bean

Affiliation Clinical and Molecular Hemostasis Laboratory Branch, Division of Blood Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

W. Craig Hooper

Affiliation Clinical and Molecular Hemostasis Laboratory Branch, Division of Blood Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

Michael R. DeBaun

Affiliation Vanderbilt School of Medicine, Nashville, Tennessee, United States of America

Melanie E. Garrett

Affiliation Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

Karen Soldano

Affiliation Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

Marilyn J. Telen

Affiliation Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

Allison Ashley-Koch

Affiliation Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

Mark T. Gladwin

Affiliation Division of Pulmonary, Allergy and Critical Care Medicine and the Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Clinton T. Baldwin

Affiliation Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America

Martin H. Steinberg

Affiliation Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America

Elizabeth S. Klings

klingon@bu.edu

Affiliations Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America, The Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PS MHS CTB ESK. Performed the experiments: JNM PS CTB NS DAD KS MEG WCH CJB. Analyzed the data: JNM NS PS CTB MHS ESK AEAK MJT MEG KS SWH PB. Contributed reagents/materials/analysis tools: MJT MRD JFC EBC CTB MHS MTG DEA. Wrote the paper: JNM PS ESK. Edited manuscript: PS MHS MTG MJT AEAK JFC MRD ESK DEA.