About the Authors

Toshimori Kitami

Affiliations Broad Institute, Cambridge, Massachusetts, United States of America, Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

David J. Logan

Affiliation Broad Institute, Cambridge, Massachusetts, United States of America

Joseph Negri

Affiliation Broad Institute, Cambridge, Massachusetts, United States of America

Thomas Hasaka

Affiliation Broad Institute, Cambridge, Massachusetts, United States of America

Nicola J. Tolliday

Affiliation Broad Institute, Cambridge, Massachusetts, United States of America

Anne E. Carpenter

Affiliation Broad Institute, Cambridge, Massachusetts, United States of America

Bruce M. Spiegelman

Affiliation Department of Cell Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

Vamsi K. Mootha

vamsi@hms.harvard.edu

Affiliations Broad Institute, Cambridge, Massachusetts, United States of America, Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Competing Interests

The authors have the following conflicts: The project was partly supported by a gift from Nestle Research Center to Dr. Mootha. There are no other declarations concerning Nestle Research Center (employment, consultancy, patents, products, or other competing interests). This gift does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: TK VKM. Performed the experiments: TK JN TH. Analyzed the data: TK DJL AEC NJT VKM. Contributed reagents/materials/analysis tools: BMS. Wrote the paper: TK VKM. Provided guidance: BMS.