Depleting Components of the THO Complex Causes Increased Telomere Length by Reducing the Expression of the Telomere-Associated Protein Rif1p

Tai-Yuan Yu; Chen-Yi Wang; Jing-Jer Lin

doi:10.1371/journal.pone.0033498

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Open Access

Peer-reviewed

Research Article

Depleting Components of the THO Complex Causes Increased Telomere Length by Reducing the Expression of the Telomere-Associated Protein Rif1p

Tai-Yuan Yu,

Affiliation Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan, People's Republic of China
⨯
Chen-Yi Wang,

Affiliation Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan, People's Republic of China
⨯
Jing-Jer Lin

* E-mail: jjlin@ym.edu.tw

Affiliations Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan, People's Republic of China, Institute of Biochemistry and Molecular Biology, National Taiwan University College of Medicine, Taipei, Taiwan, People's Republic of China
⨯

Depleting Components of the THO Complex Causes Increased Telomere Length by Reducing the Expression of the Telomere-Associated Protein Rif1p

Tai-Yuan Yu,
Chen-Yi Wang,
Jing-Jer Lin

Published: March 20, 2012
https://doi.org/10.1371/journal.pone.0033498

About the Authors

Tai-Yuan Yu

Affiliation Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan, People's Republic of China

Chen-Yi Wang

Affiliation Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan, People's Republic of China

Jing-Jer Lin

* E-mail: jjlin@ym.edu.tw

Affiliations Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan, People's Republic of China, Institute of Biochemistry and Molecular Biology, National Taiwan University College of Medicine, Taipei, Taiwan, People's Republic of China

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TYY CYW JJL. Performed the experiments: TYY CYW. Analyzed the data: TYY CYW JJL. Contributed reagents/materials/analysis tools: TYY CYW. Wrote the paper: TYY JJL.

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Telomeres
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Telomere length
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Yeast
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Saccharomyces cerevisiae
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DNA transcription
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RNA analysis
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Silent mutation
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Gene expression
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