About the Authors

M. Ann Kelly

m.a.kelly@bham.ac.uk

Affiliations College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, BioMedical Research Centre, Heart of England NHS Foundation Trust, Birmingham, United Kingdom

Simon D. Rees

Affiliations College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, BioMedical Research Centre, Heart of England NHS Foundation Trust, Birmingham, United Kingdom

M. Zafar I. Hydrie

Affiliation Baqai Institute of Diabetology and Endocrinology (BIDE), Karachi, Pakistan

A. Samad Shera

Affiliation Diabetic Association of Pakistan, Karachi, Pakistan

Srikanth Bellary

Affiliations BioMedical Research Centre, Heart of England NHS Foundation Trust, Birmingham, United Kingdom, School of Life and Health Sciences, Aston University, Birmingham, United Kingdom

J. Paul O’Hare

Affiliation Warwick Medical School, University of Warwick, Coventry, United Kingdom

Sudhesh Kumar

Affiliation Warwick Medical School, University of Warwick, Coventry, United Kingdom

Shahrad Taheri

Affiliations College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, BioMedical Research Centre, Heart of England NHS Foundation Trust, Birmingham, United Kingdom

Abdul Basit

Affiliation Baqai Institute of Diabetology and Endocrinology (BIDE), Karachi, Pakistan

Anthony H. Barnett

Affiliation BioMedical Research Centre, Heart of England NHS Foundation Trust, Birmingham, United Kingdom

DIAGRAM consortium

Members of the DIAGRAM and SAT2D consortia are listed in the Acknowledgements.

SAT2D consortium

Members of the DIAGRAM and SAT2D consortia are listed in the Acknowledgements.

Competing Interests

We have read the journal’s policy and have the following conflicts. This study was partly funded by Eli Lilly. Professor Sudhesh Kumar has received lecture fees and research funding from Eli Lilly. Professor Anthony Barnett has received honoraria from Eli Lilly for lectures and advisory work, and has received research funding from Eli Lilly. Dr. Shahrad Taheri has received educational funding support from Eli Lilly. The United Kingdom Asian Diabetes Study was supported by Pfizer, Sanofi-Aventis, Servier Laboratories United Kingdom, Merck Sharp & Dohme/Schering-Plough, Takeda United Kingdom, Roche, Merck Pharma, Daiichi-Sankyo United Kingdom, Boehringer Ingelheim, Eli Lilly, Novo Nordisk, Bristol-Myers Squibb, Solvay Health Care and Assurance Medical Society UK. Professor Barnett has received research funding and honoraria for lecturing and advisory work from these sources. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MAK ST. Performed the experiments: SDR. Analyzed the data: SDR. Contributed reagents/materials/analysis tools: MZIH ASS SB JPO SK AB AHB. Wrote the paper: MAK. Contributed to discussion and reviewed/edited the manuscript: SDR MZIH ASS SB JPO SK ST AB.