About the Authors

Tamara R. Castañeda

Affiliation Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Düsseldorf, Germany

William Abplanalp

Affiliation Metabolic Disease Institute, Division of Endocrinology, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

Sung Hee Um

Affiliations Department of Molecular Oncogenesis, Metabolic Disease Institute, University of Cincinnati, Cincinnati, Ohio, United States of America, Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Seoul, South Korea

Paul T. Pfluger

Affiliation HelmholtzZentrum München, German Research Center for Environmental Health (GmbH), Neuherberg/Munich, Germany

Brigitte Schrott

Affiliation Metabolic Disease Institute, Division of Endocrinology, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

Kimberly Brown

Affiliation Metabolic Disease Institute, Division of Endocrinology, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

Erin Grant

Affiliation Metabolic Disease Institute, Division of Endocrinology, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

Larissa Carnevalli

Affiliation Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), Germany Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany

Stephen C. Benoit

Affiliation Metabolic Disease Institute, Division of Endocrinology, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

Donald A. Morgan

Affiliation Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City, Iowa, United States of America

Dean Gilham

Affiliation Resverlogix Corporation (TSX:RVX), NW Calgary, Alberta, Canada

David Y. Hui

Affiliation Department of Pathology, Centre of Arteriosclerosis Studies, Metabolic Disease Institute, University of Cincinnati, Cincinnati, Ohio, United States of America

Kamal Rahmouni

Affiliation Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City, Iowa, United States of America

George Thomas

Affiliation Department of Molecular Oncogenesis, Metabolic Disease Institute, University of Cincinnati, Cincinnati, Ohio, United States of America

Sara C. Kozma

Affiliation Department of Molecular Oncogenesis, Metabolic Disease Institute, University of Cincinnati, Cincinnati, Ohio, United States of America

Deborah J. Clegg

Affiliation Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Matthias H. Tschöp

matthias.tschoep@helmholtz-muenchen.de

Affiliation HelmholtzZentrum München, German Research Center for Environmental Health (GmbH), Neuherberg/Munich, Germany

Competing Interests

The work done by DG was carried out while he was a post-doc at the University of Cincinnati, after which he moved to Resverlogix. Hence Resverlogix is not affiliated with the work or the materials used in the publication in any way, and there is no competing interest associated with Resverlogix. This does not alter the authors′ adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MHT DJC DYH SCB GT SCK. Performed the experiments: TRC WA SHU PTP BS KB EG LC DAM DG. Analyzed the data: TRC. Contributed reagents/materials/analysis tools: MHT GT SK DH KR. Wrote the paper: TRC MHT DJC DYH SCB GT SK. Interpreted data: MHT DJC DYH SCB GT SK. Co-edited manuscript: WA SHU EG LC DG.