About the Authors

Tomoko Kanao

Affiliation Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan

Tomoyo Sawada

Affiliations Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan, CREST (Core Research for Evolutionary Science and Technology), JST, Saitama, Japan

Shireen-Anne Davies

Affiliation Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom

Hiroshi Ichinose

Affiliation Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan

Kazuko Hasegawa

Affiliation Department of Neurology, National Hospital Organization, Sagamihara National Hospital, Sagamihara, Japan

Ryosuke Takahashi

Affiliations Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan, CREST (Core Research for Evolutionary Science and Technology), JST, Saitama, Japan

Nobutaka Hattori

Affiliations Department of Neurology, Juntendo University Graduate School of Medicine, Tokyo, Japan, CREST (Core Research for Evolutionary Science and Technology), JST, Saitama, Japan

Yuzuru Imai

yzimai@juntendo.ac.jp

Affiliation Department of Neuroscience for Neurodegenerative Disorders, Juntendo University Graduate School of Medicine, Tokyo, Japan

Competing Interests

The authors have read the journal's policy and have the following conflicts: this work was partly supported by Dainippon Sumitomo Pharma. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: TK YI. Performed the experiments: TK TS YI. Analyzed the data: TK YI. Contributed reagents/materials/analysis tools: TS SD HI KH RT NH. Wrote the paper: YI.