Structural and Spectroscopic Analysis of the Kinase Inhibitor Bosutinib and an Isomer of Bosutinib Binding to the Abl Tyrosine Kinase Domain

Nicholas M. Levinson; Steven G. Boxer

doi:10.1371/journal.pone.0029828

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Open Access

Peer-reviewed

Research Article

Structural and Spectroscopic Analysis of the Kinase Inhibitor Bosutinib and an Isomer of Bosutinib Binding to the Abl Tyrosine Kinase Domain

Nicholas M. Levinson ,

* E-mail: nickl@stanford.edu

Affiliation Department of Chemistry, Stanford University, Stanford, California, United States of America
⨯
Steven G. Boxer

Structural and Spectroscopic Analysis of the Kinase Inhibitor Bosutinib and an Isomer of Bosutinib Binding to the Abl Tyrosine Kinase Domain

Nicholas M. Levinson,
Steven G. Boxer

Published: April 6, 2012
https://doi.org/10.1371/journal.pone.0029828

About the Authors

Nicholas M. Levinson

* E-mail: nickl@stanford.edu

Affiliation Department of Chemistry, Stanford University, Stanford, California, United States of America

Steven G. Boxer

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NML SGB. Performed the experiments: NML. Analyzed the data: NML. Contributed reagents/materials/analysis tools: NML. Wrote the paper: NML.

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Isomers
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Nitriles
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Crystal structure
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Anilines
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Protein kinases
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Chlorine
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Fluorescence
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Tyrosine kinases
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