About the Authors
- Burcin Ekser
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Affiliations Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America, Department of Surgery, Transplantation and Advanced Technologies, Vascular Surgery and Organ Transplant Unit, University Hospital of Catania, Catania, Italy
- Edwin Klein
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Affiliation Division of Laboratory Animal Resources, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
- Jing He
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Affiliation Division of Immunogenetics, Department of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
- Donna B. Stolz
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Affiliation Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
- Gabriel J. Echeverri
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Affiliations Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), Palermo, Italy
- Cassandra Long
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Affiliation Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
- Chih Che Lin
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Affiliation Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
- Mohamed Ezzelarab
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Affiliation Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
- Hidetaka Hara
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Affiliation Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
- Massimiliano Veroux
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Affiliation Department of Surgery, Transplantation and Advanced Technologies, Vascular Surgery and Organ Transplant Unit, University Hospital of Catania, Catania, Italy
- David Ayares
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Affiliation Revivicor Inc., Blacksburg, Virginia, United States of America
- David K. C. Cooper
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* E-mail: cooperdk@upmc.edu
Affiliation Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
- Bruno Gridelli
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Affiliations Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), Palermo, Italy
Competing Interests
David Ayares owns stock in Revivicor, Inc. The other authors declare no conflict of interest. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.
Author Contributions
Performed in vitro assays and in vivo procedures: CL CCL GJE ME HH BE. Performed animal care and follow-up: BE. Supervised the production of genetically-engineered pigs: DA. Co-designed the study and experiments: DKCC BG. Assisted with surgeries: CL CCL GJE ME HH. Participated in the surgical procedures: DKCC. Performed the surgical procedures: BG BE. Performed light microscopy and interpretation: EK. Performed immunohistological studies: JH. Performed electron microscopy: DBS. Participated in preparation and discussion of the manuscript: MV. Co-wrote the manuscript: DKCC BG BE. All authors advised on the writing of the manuscript.