About the Authors

Anna Falk

Contributed equally to this work with: Anna Falk, Philipp Koch

Affiliation Department of Biochemistry, Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, United Kingdom

Philipp Koch

Contributed equally to this work with: Anna Falk, Philipp Koch

Affiliation Institute of Reconstructive Neurobiology, LIFE & BRAIN Center, University of Bonn and Hertie Foundation, Bonn, Germany

Jaideep Kesavan

Affiliation Institute of Reconstructive Neurobiology, LIFE & BRAIN Center, University of Bonn and Hertie Foundation, Bonn, Germany

Yasuhiro Takashima

Affiliation Department of Biochemistry, Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, United Kingdom

Julia Ladewig

Affiliation Institute of Reconstructive Neurobiology, LIFE & BRAIN Center, University of Bonn and Hertie Foundation, Bonn, Germany

Michael Alexander

Affiliation Institute of Human Genetics, LIFE & BRAIN Center, University of Bonn, Bonn, Germany

Ole Wiskow

Affiliation Department of Biochemistry, Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, United Kingdom

Jignesh Tailor

Affiliation Department of Biochemistry, Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, United Kingdom

Matthew Trotter

Affiliation Anne McLaren Laboratory for Regenerative Medicine, University of Cambridge, Cambridge, United Kingdom

Steven Pollard

Current address: Samantha Dickson Brain Cancer Unit and UCL Cancer Institute, University College London, London, United Kingdom

Affiliation Department of Biochemistry, Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, United Kingdom

Austin Smith

Affiliation Department of Biochemistry, Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, United Kingdom

Oliver Brüstle

brustle@uni-bonn.de

Affiliation Institute of Reconstructive Neurobiology, LIFE & BRAIN Center, University of Bonn and Hertie Foundation, Bonn, Germany

Competing Interests

OB is a co-founder of and has stock in LIFE & BRAIN GmbH. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AF PK AS OB. Performed the experiments: AF PK JK YT JL OW JT. Analyzed the data: AF PK MT AS OB. Contributed reagents/materials/analysis tools: MA SP. Wrote the paper: AF PK MT AS OB.