Two Lysines in the Forkhead Domain of Foxp3 Are Key to T Regulatory Cell Function

Yujie Liu; Liqing Wang; Rongxiang Han; Ulf H. Beier; Wayne W. Hancock

doi:10.1371/journal.pone.0029035

Loading metrics

Open Access

Peer-reviewed

Research Article

Two Lysines in the Forkhead Domain of Foxp3 Are Key to T Regulatory Cell Function

Yujie Liu,

Affiliation Laboratory of Medicine, Division of Transplant Immunology, Department of Pathology, School of Medicine, University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Liqing Wang,

Affiliation Laboratory of Medicine, Division of Transplant Immunology, Department of Pathology, School of Medicine, University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Rongxiang Han,

Affiliation Laboratory of Medicine, Division of Transplant Immunology, Department of Pathology, School of Medicine, University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Ulf H. Beier,

Affiliation Division of Nephrology, Department of Pediatrics, School of Medicine, University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Wayne W. Hancock

* E-mail: whancock@mail.med.upenn.edu

Affiliation Laboratory of Medicine, Division of Transplant Immunology, Department of Pathology, School of Medicine, University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯

Two Lysines in the Forkhead Domain of Foxp3 Are Key to T Regulatory Cell Function

Yujie Liu,
Liqing Wang,
Rongxiang Han,
Ulf H. Beier,
Wayne W. Hancock

Published: January 11, 2012
https://doi.org/10.1371/journal.pone.0029035

About the Authors

Yujie Liu

Affiliation Laboratory of Medicine, Division of Transplant Immunology, Department of Pathology, School of Medicine, University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Liqing Wang

Rongxiang Han

Ulf H. Beier

Affiliation Division of Nephrology, Department of Pediatrics, School of Medicine, University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Wayne W. Hancock

* E-mail: whancock@mail.med.upenn.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YL WWH. Performed the experiments: YL LW RH UHB. Analyzed the data: YL UHB WWH. Wrote the paper: YL WWH.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.
Regulatory T cells
Is the Subject Area "Regulatory T cells" applicable to this article?

Thanks for your feedback.
Lysine
Is the Subject Area "Lysine" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
DNA-binding proteins
Is the Subject Area "DNA-binding proteins" applicable to this article?

Thanks for your feedback.
Acetylation
Is the Subject Area "Acetylation" applicable to this article?

Thanks for your feedback.
Cell binding
Is the Subject Area "Cell binding" applicable to this article?

Thanks for your feedback.
Forkhead box
Is the Subject Area "Forkhead box" applicable to this article?

Thanks for your feedback.