Epigenetic Silencing of IRF7 and/or IRF5 in Lung Cancer Cells Leads to Increased Sensitivity to Oncolytic Viruses

Qunfang Li; Michael A. Tainsky

doi:10.1371/journal.pone.0028683

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Open Access

Peer-reviewed

Research Article

Epigenetic Silencing of IRF7 and/or IRF5 in Lung Cancer Cells Leads to Increased Sensitivity to Oncolytic Viruses

Qunfang Li,

Affiliations Program in Molecular Biology and Genetics, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States of America, Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Michael A. Tainsky

* E-mail: tainskym@karmanos.org

Affiliations Program in Molecular Biology and Genetics, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States of America, Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯

Epigenetic Silencing of IRF7 and/or IRF5 in Lung Cancer Cells Leads to Increased Sensitivity to Oncolytic Viruses

Qunfang Li,
Michael A. Tainsky

Published: December 14, 2011
https://doi.org/10.1371/journal.pone.0028683

About the Authors

Qunfang Li

Affiliations Program in Molecular Biology and Genetics, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States of America, Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan, United States of America

Michael A. Tainsky

* E-mail: tainskym@karmanos.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: QL MAT. Performed the experiments: QL. Analyzed the data: QL. Contributed reagents/materials/analysis tools: QL MAT. Wrote the paper: QL MAT.

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Lung and intrathoracic tumors
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Cancer treatment
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DNA methylation
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Vesicular stomatitis virus
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Oncolytic viruses
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Prostate cancer
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Epigenetics
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Innate immune system
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