About the Authors

Ji-Dong Fu

Affiliation University of California School of Medicine, Davis, California, United States of America

Stephanie N. Rushing

Affiliations University of California School of Medicine, Davis, California, United States of America, Center of Cardiovascular Research, Mount Sinai School of Medicine, New York, New York, United States of America

Deborah K. Lieu

Affiliations University of California School of Medicine, Davis, California, United States of America, Center of Cardiovascular Research, Mount Sinai School of Medicine, New York, New York, United States of America

Camie W. Chan

Affiliations University of California School of Medicine, Davis, California, United States of America, Department of Medicine, The University of Hong Kong, Hong Kong, Department of Anatomy, The University of Hong Kong, Hong Kong

Chi-Wing Kong

Affiliations Department of Medicine, The University of Hong Kong, Hong Kong, Stem Cell and Regenerative Medicine Consortium, The University of Hong Kong, Hong Kong, Heart, Brain, Hormone and Healthy Aging Research Center, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong

Lin Geng

Affiliation Stem Cell and Regenerative Medicine Consortium, The University of Hong Kong, Hong Kong

Kitchener D. Wilson

Affiliation Departments of Medicine and Radiology, Stanford University, Palo Alto, California, United States of America

Nipavan Chiamvimonvat

Affiliation University of California School of Medicine, Davis, California, United States of America

Kenneth R. Boheler

Affiliations Stem Cell and Regenerative Medicine Consortium, The University of Hong Kong, Hong Kong, Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Joseph C. Wu

Affiliation Departments of Medicine and Radiology, Stanford University, Palo Alto, California, United States of America

Gordon Keller

Affiliation McEwen Central for Regenerative Medicine, University Health Network, Toronto, Ontario, Canada

Roger J. Hajjar

Affiliation Center of Cardiovascular Research, Mount Sinai School of Medicine, New York, New York, United States of America

Ronald A. Li

ronald.li@mssm.edu

Affiliations University of California School of Medicine, Davis, California, United States of America, Center of Cardiovascular Research, Mount Sinai School of Medicine, New York, New York, United States of America, Department of Medicine, The University of Hong Kong, Hong Kong, Department of Physiology, The University of Hong Kong, Hong Kong, Stem Cell and Regenerative Medicine Consortium, The University of Hong Kong, Hong Kong, Heart, Brain, Hormone and Healthy Aging Research Center, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong

Competing Interests

This work has received support from VistaGen Therapeutics, Inc., South San Francisco, CA. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: RAL JCW DKL CWC. Performed the experiments: JDF SNR DKL CWK LG KDW. Analyzed the data: JDF SNR DKL CWK LG KDW KRB. Contributed reagents/materials/analysis tools: RAL GK RJH NC. Wrote the paper: RAL JDF SNR.