About the Authors

Alex F. Bokov

Contributed equally to this work with: Alex F. Bokov, Neha Garg, Yuji Ikeno

Affiliations Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

Neha Garg

Contributed equally to this work with: Alex F. Bokov, Neha Garg, Yuji Ikeno

Affiliation Department of Biochemistry, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

Yuji Ikeno

Contributed equally to this work with: Alex F. Bokov, Neha Garg, Yuji Ikeno

Affiliations Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Geriatric Research, Education, and Clinical Center (GRECC), South Texas Veterans Health Care System, San Antonio, Texas, United States of America

Sachin Thakur

Affiliation Department of Biochemistry, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

Nicolas Musi

Affiliations Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Geriatric Research, Education, and Clinical Center (GRECC), South Texas Veterans Health Care System, San Antonio, Texas, United States of America

Ralph A. DeFronzo

Affiliation Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

Ning Zhang

Affiliation Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

Rebecca C. Erickson

Affiliation College of Natural Sciences, University of Texas at Austin, Austin, Texas, United States of America

Jon Gelfond

Affiliations Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Epidemiology and Biostatistics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

Gene B. Hubbard

Affiliations Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

Martin L. Adamo

Affiliations Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Biochemistry, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

Arlan Richardson

Richardson@uthscsa.edu

Affiliations Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Geriatric Research, Education, and Clinical Center (GRECC), South Texas Veterans Health Care System, San Antonio, Texas, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AFB AR NG MLA. Performed the experiments: AFB NG ST RCE. Analyzed the data: AFB JG. Contributed reagents/materials/analysis tools: AR MLA. Wrote the paper: AFB AR. Euglycemic hyperinsulinemic clamp: NZ RAD NM. Histopathology: GBH YI.