About the Authors

Kah Yong Tan

Affiliations Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, Massachusetts, United Stated of America, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, United Stated of America, Harvard Stem Cell Institute, Cambridge, Massachusetts, United Stated of America, Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United Stated of America

Sarah Eminli

Affiliations Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, United Stated of America, Harvard Stem Cell Institute, Cambridge, Massachusetts, United Stated of America, Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine, Boston, Massachusetts, United Stated of America, Department of Biology, Chemistry and Pharmacy, Free University of Berlin, Berlin, Germany

Simone Hettmer

Affiliations Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, Massachusetts, United Stated of America, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, United Stated of America, Harvard Stem Cell Institute, Cambridge, Massachusetts, United Stated of America, Department of Pediatric Oncology, Dana Farber Cancer Institute and Division of Pediatric Hematology/Oncology, Children's Hospital, Boston, Massachusetts, United Stated of America

Konrad Hochedlinger

Affiliations Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, United Stated of America, Harvard Stem Cell Institute, Cambridge, Massachusetts, United Stated of America, Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine, Boston, Massachusetts, United Stated of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

Amy J. Wagers

amy.wagers@joslin.harvard.edu

Affiliations Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, Massachusetts, United Stated of America, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, United Stated of America, Harvard Stem Cell Institute, Cambridge, Massachusetts, United Stated of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

Competing Interests

The authors have read the journal's policy and have the following conflicts: KH and AW were previously on the scientific advisory board for iPierian, inc. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: KH AJW. Performed the experiments: KT SE SH. Analyzed the data: KT SE. Contributed reagents/materials/analysis tools: KH AJW. Wrote the paper: KT AJW.